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Malignant hypertension (arteriolar nephrosclerosis)
Alternative namesAccelerated hypertension; Arteriolar nephrosclerosis; Nephrosclerosis - arteriolar; Hypertension - malignant
DefinitionMalignant hypertension is usually defined as very high blood pressure with swelling of the optic nerve behind the eye, called papilledema (grade IV Keith-Wagner hypertensive retinopathy). Malignant hypertension is usually accompanied by other organ damage like heart failure, kidney failure, and hypertensive encephalopathy.
Causes, incidence, and risk factors
The disorder affects about 1% of people with high blood pressure, including both children and adults. It is more common in younger adults, especially African American men. It also occurs in women with toxemia of pregnancy , and people with kidney disorders or collagen vascular disorders . You are at high risk for malignant hypertension if you have had kidney (renal) failure or renal hypertension caused by renal artery stenosis .
Signs and testsYour blood pressure may be extremely high. An eye examination will reveal changes that indicate high blood pressure, including papilledema (swelling of the optic nerve), retinal bleeding, or infarction (cotton wool spots or soft exudate -- fluid with cellular debris) in the retina . If not already present, kidney failure may develop as a complication of malignant hypertension. Other complications may also develop.
Damage to the kidneys may be demonstrated by:
This disease may also alter the results of the following tests:
TreatmentHospitalization is essential until the severe high blood pressure is under control. Medications delivered through an IV line, such as nitroprusside, nitroglycerin, or others, may reduce your blood pressure.
After the severe high blood pressure is brought under control, anti-hypertensive medications taken by mouth can control your blood pressure. The medication may need to be adjusted occasionally. Hypertension can be difficult to control.
Expectations (prognosis)If treated promptly, malignant hypertension is often controlled without permanent complications. If it is not treated promptly, complications may be severe and life-threatening.
Calling your health care provider
Go to the emergency room or call your local emergency number (such as 911) if symptoms of malignant hypertension develop. This is an emergency condition!
Call your health care provider if you know you have poorly controlled high blood pressure.
PreventionIf you have high blood pressure, carefully monitoring your blood pressure and taking your medicines properly help to reduce the risk.
Update Date: 10/29/2003Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT