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24-hour urine protein
Alternative names24-hour urine protein measures the amount of protein excreted in urine over a 24-hour period.
How the test is performedA 24-hour urine sample is needed. The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
This procedure may take a couple of attempts -- lively infants can displace the bag, causing the specimen to be absorbed by the diaper. The infant should be checked frequently and the bag changed after the infant has urinated into the bag. The urine is drained into the container for transport to the laboratory.
How to prepare for the testNo special preparation is necessary for this test, but if the collection is being taken from an infant, a couple of extra collection bags may be necessary.
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performed
The test determines the amount of protein that is excreted in the urine in 1 day.
Smaller quantities of albumin and globulins are also present in the urine. Most of the filtered proteins are normally reabsorbed by the proximal tubular cells of the kidney.
Normal ValuesThe normal value is less than 150 mg/day, or less than 10 mg/dl. Normal value ranges may vary slightly among different laboratories.
Note: mg/day = milligrams per day; mg/dl = milligrams per deciliter (of urine)
What abnormal results mean
Increased urinary protein is usually measured when glomerular disease is suspected. The deterioration in the integrity of the glomerulus allows albumin to permeate in large quantities. Glomerular disease, such as nephrotic syndrome may result in urine protein (mostly urine albumin) of greater than 3.5 gm/day. So-called microalbuminuria with urine albumin levels of 30 to 200 mg/day is considered an early sign of diabetic nephropathy .
What the risks areThere are no risks.
Special considerationsHealthy people may exceed normal protein excretion levels after strenuous exercise or with dehydration. Some foods may affect protein levels.
Drugs that can cause increased excretion levels include acetaminophen, antibiotics, gentamicin, and non-steroidal anti-inflammatory drugs (when associated with analgesic nephropathy).
Update Date: 2/11/2004Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT