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DefinitionThis is a test that measures the amount of pregnanediol in urine.
How the test is performedA 24-hour urine sample is needed. The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
How to prepare for the testThe health care provider may advise you to discontinue drugs that can affect the test. (See "Special Considerations".)
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performed
This test is usually performed to evaluate suspected problems with the ovaries or adrenal cortex. In the past, before progesterone blood tests, this test was also used to document problems of pregnancy.
Pregnanediol is an inactive product of progesterone metabolism . Urinary pregnanediol is an indirect measure of progesterone levels in the body. In women, progesterone is produced mainly by the corpus luteum following ovulation. Some progesterone is also produced by the adrenal cortex.
During pregnancy, most progesterone is produced by the placenta. The main function of progesterone is probably to increase the secretory phase of endometrial development, during which the uterus is prepared for possible implantation by a fertilized egg. After fertilization, progesterone is necessary for the development and maintenance of the placenta.
What abnormal results meanHigher-than-normal levels may indicate:
What the risks areThere are no risks.
Update Date: 7/30/2003Douglas A. Levine, M.D., Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, NY. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT