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Vertebrobasilar circulatory disorders

Alternative names

Vertebrobasilar insufficiency; Posterior circulation ischemia.


Vertebrobasilar circulatory disorders is a group of disorders in which blood supply to the back of the brain is disrupted.

Causes, incidence, and risk factors

The vertebrobasilar system is also called the "posterior circulation" of the brain. There are three main vessels which provide circulation to the back of the brain -- two vertebral arteries and one basilar artery.

The back of the brain contains structures which are crucial for sustaining life. For instance, the brainstem controls respiration, swallowing, and the level of consciousness. Other structures of the back of the brain are the occipital lobes (the vision areas of the brain) and the cerebellum (which controls motor coordination).

Blood flow in the posterior circulation of the brain can be disrupted by many different conditions. The most common cause is stroke caused by hardening of the arteries (atherosclerosis).

This can occur when fat accummulates in a blood vessel wall, causing local inflammation (irritation and swelling with presence of extra immune cells). The areas of inflammation are called "plaques," and they can break off and cause blood clots inside of the vessel.

These clots can then travel inside the arteries and get stuck in the brain, blocking the blood supply to the area normally fed by the artery. This abrupt stop of blood supply causes rapid malfunction and even death of the affected brain cells, which are very sensitive to lack of circulation. This is what happens when a person suffers one type of stroke .

VCD also can be caused by so-called "dissection," which is a tear of the artery wall. This involves bleeding through the artery wall and sometimes the release of a clot which then blocks blood flow.

Dissection can be caused by plaques, other diseases of the arteries (such as "fibro-muscular dysplasia"), or it can be caused by trauma (such as a car accident). It may even be caused by manipulations of the neck by a chiropractor or during massage.

However, most of the time, no apparent cause of dissection can be identified. Other less common causes of vertebrobasilar vascular disorders include connective tissue diseases (for instance lupus and other forms of arthritis) or vasculitis .


  • Loss of vision, particularly affecting same part of the visual field on both eyes
  • Double vision
  • Vertigo (sensation of things spinning around)
  • Numbness or tingling
  • Nausea/vomiting
  • Difficulty swallowing
  • Problems with balance
  • Poor coordination
  • Headache
  • Neckache
  • Loss of hearing
  • Change in voice (for instance, slurring of the speech, like being drunk)

Signs and tests

Tests will be ordered based on what the underlying cause is likely to be. These may include:

  • Imaging test of the brain ("pictures" of the brain), especially CAT scans and MRI
  • Imaging of the blood vessels including MRI angiography (MRA) or ultrasound
  • Imaging of the heart (Echocardiogram)
  • Conventional angiogram (X-rays of the arteries using injected dye)
  • Lumbar puncture (spinal tap) (rarely needed)
  • Blood tests
  • Electrocardiogram (EKG) / Holter monitor (a prolonged EKG to look for abnormal heart rhythms)
  • X-rays
  • Computed tomography angiography (CTA), another type of blood vessel imaging

Occasionally, some special coagulation tests are requested whenever the diagnosis is unclear, to see if the patient has an abnormal tendency to form clots.


Management can be divided into emergency treatment and the prevention of recurrences. It is critical to seek medical attention as fast as possible. A stroke is a "brain attack" and this type of stroke is one in which rapid medical attention can be the difference between life and death or between mild and severe disability.

When the patient arrives to the hospital within 3 hours after the onset of symptoms, the use of a medication called "t-PA," can be considered. This medication is a "clot buster," which is given intravenously (injected into the veins), and has been shown to improve the chances of a meaningful recovery.

Unfortunately, t-PA is a potentially dangerous drug because it can cause bleeding in the brain. Since it can be hard to tell whether a stroke has been caused by a clot or by bleeding, and since giving this medication in the case of a stroke caused by bleeding could be fatal, careful evaluation must be done. Physicians need to order several tests and do careful physical examinations to make sure that t-PA is the right treatment.

In some cases, physicians may deliver the clot buster using a small catheter inserted through the skin, which is then advanced to the blocked area of the brain circulation with the aid of X-ray angiography.

This may be tried when the patient arrives too late for the 3-hour window required for the intravenous t-PA. It is unclear at this time, however, if this is better than using other treatments.

The prevention of new strokes depends on the underlying cause. It is always critically important that blood pressure, heart conditions, blood sugar, and cholesterol problems are all addressed.

When plaques have caused a stroke, blood thinners that block the function of some sticky cells of the blood (the "platelets") can be used. The most important of these drugs is aspirin.

However, some other drugs of similar efficacy are available, like clopidogrel, ticlopidine, and dipyridamole. One recent European study showed that the combination of two of these "anti-platelet" drugs (aspirin and dipyridamole) is better than either drug alone to prevent first or recurring strokes.

If a dissection is found, it may be left to resolve on its own or treated with aspirin or warfarin (another blood thinner) for 3-6 months.

If there is a significant blockage of a blood vessel, an "angioplasty" can open up the artery with a balloon, and a stent can be used to keep it open. However, stents are not universally available and contrarily, their placement may cause a stroke.

If vascular problems exist as a result of another illness (such as vasculitis) steroids or other immune-suppressing drugs may be used.

Expectations (prognosis)

Prognosis depends in part on the underlying cause. Strokes of the brainstem region are potentially life-threatening and demand urgent medical care. The most important prognostic factors are age and associated medical problems.

When patients are young and have no significant medical problems, a substantial recovery can be expected.

Recovery also depends upon the area of the brain that has been affected. The prognosis is very poor when the patient is in coma or can not move both arms and legs.

The complications of stroke are respiratory failure (which may require use of mechanical respiration), lung problems (especially lung infections), heart attack, dehydration and swallowing problems (sometimes leading to the placement of tubes in the stomach for artificial feeding), problems with movement and/or sensation including paralysis, and numbness and the formation of clots in the legs.


Complications of vertebrobasilar circulatory disorders are stroke and its complications listed above including severe disability. Also, complications caused by medications or surgery can occur.

Calling your health care provider

Call 911 or other local emergency number or get to the emergency room if you have any symptoms that may suggest a vertebrobasilar circulatory disorder. Remember the motto of the stroke neurologist -- "Time is brain."


Prevention of strokes caused by these disorders includes cessation of smoking , regular exercise, blood pressure control, healthy diet , and managing of diabetes. Prevention of dissection includes avoidance of neck manipulation and trauma to the neck.

Update Date: 8/1/2002

Lucas Restrepo, M.D., Clinical Instructor, Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, Review provided by VeriMed Healthcare Network.

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT