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24-hour urinary aldosterone excretion rate
Alternative names24-hour urinary aldosterone excretion rate test measures the amount of aldosterone eliminated in the urine in a day (see the blood aldosterone test).
How the test is performedA 24-hour urine sample is needed. The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
This procedure may take a couple of attempts -- lively infants can displace the bag, causing the specimen to be absorbed by the diaper. The infant should be checked frequently and the bag changed after the infant has urinated into the bag. The urine is drained into the container for transport to the laboratory.
Deliver it to the laboratory or your health care provider as soon as possible upon completion. The lab analyzes the sample for the amount of aldosterone.
How to prepare for the testNo special preparation is necessary for this test, but if the collection is being taken from an infant, a couple of extra collection bags may be necessary.
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performedThe test evaluates the excretion of aldosterone in the urine. Aldosterone is a hormone secreted by the adrenal gland which acts on the kidney to regulate salt and potassium balance.
Normal ValuesNormal values range from 6 to 25 mcg/24 hours. (This depends on the amount of sodium excreted by the body. The greater the amount of sodium, the lower the level of aldosterone .) Normal value ranges may vary slightly among different laboratories.
Note: mcg/24 hr = micrograms per 24 hours
What abnormal results meanGreater than normal levels of aldosterone may indicate:
What the risks areThere are no risks.
Special considerationsThe results may be questionable, if the renal function is not normal.
Nonpharmacological factors that can affect aldosterone measurements include: strenuous exercise, acute stress, high- or low-sodium diet, and pregnancy.
Drugs that can increase aldosterone measurements include: lithium, spironolactone, and verapamil.
Drugs that can decrease aldosterone measurements include: ACE inhibitors, NSAIDS, ranitidine, and propranolol.
Update Date: 2/2/2004Tarun Jain, M.D., Endocrinology & Infertility Division, Brigham and Women's Hospital, Boston, MA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT