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Leucine aminopeptidase - urine
Alternative namesLAP - urine; Urine LAP
DefinitionThis is a test that measures the amount of leucine aminopeptidase (LAP) in urine.
How the test is performedA 24-hour urine sample is needed. The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test (see special considerations).
For an infant, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on your infant. For males, the entire penis can be placed in the bag and the adhesive attached to the skin. For females, the bag is placed over the labia. Place a diaper over the infant (bag and all).
The infant should be checked frequently and the bag changed after the infant has urinated into the bag. For active infants, this procedure may take a couple of attempts -- lively infants can displace the bag, causing an inability to obtain the specimen. The urine is drained into the container for transport to the laboratory.
How to prepare for the testNo special preparation is necessary for this test, but if the collection is being taken from an infant, a couple of extra collection bags may be necessary.
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performedUnlike other liver enzymes, LAP can be measured in the urine. This test may be appropriate in some cases as a screening test or to avoid the risks of having blood drawn. This test is performed much less commonly than the LAP blood test ( leucine aminopeptidase - serum ).
LAP is a proteolytic enzyme that breaks chemical bonds in proteins at specific sites next to leucine amino acids . Serum (blood) LAP is measured to diagnose liver dysfunction. However, LAP is made by virtually all tissues. Elevations are also seen in several cancers and systemic lupus erythematosus (SLE).
Normal ValuesNormal values range from 2-18 units per 24 hours.
What abnormal results mean
Elevated levels of LAP can be seen in several conditions:
What the risks areThere is essentially no risk.
Special considerationsDrugs that can affect LAP measurements include estrogens and progesterones (see Progestins - oral).
Update Date: 2/9/2004Frank A. Greco, M.D., Ph.D., Director, Biophysical Laboratory, The Lahey Clinic, Burlington, MA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT