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Alternative namesInheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant
The term "sex-linked dominant" means that a single abnormal gene on the X chromosome can cause the disease. The disease is likely to be transmitted to boys and girls. However, boys may not survive. This is a rare mode of transmission.
Related terms and topics:
The inheritance of genetic diseases, abnormalities, or traits is described by both the type of chromosome the abnormal gene resides on (autosomal or sex chromosome), and by whether the gene itself is dominant or recessive.
Autosomally inherited diseases are inherited through the non-sex chromosomes, pairs 1 through 22. Sex-linked diseases are inherited through one of the "sex chromosomes" (the X chromosome or the Y chromosome).
Dominant inheritance occurs when an abnormal gene from ONE parent is capable of causing disease even though there may be a matching gene from the other parent that is normal. The abnormal gene dominates the outcome of the gene pair.
For an X-linked dominant disorder: If the father carries the abnormal X gene, all of his daughters will inherit the disease and none of the sons will have the disease. If the mother carries the abnormal X gene half of all their children (daughters and sons) will inherit the disease tendency.
This does not mean that children WILL necessarily be affected.
Update Date: 8/27/2003Douglas R. Stewart, M.D., Division of Medical Genetics, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT