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Alternative namesTremor - familial
DefinitionFamilial tremor is a neurologic disorder that tends to run in families, involving involuntary shaking (tremors ) that typically gets worse when the affected person tries to move or become more active.
Causes, incidence, and risk factors
There is overlap between essential tremor , which may occur as an isolated case but may also run in families, and familial tremor, which affects more than one person in a family. Tremors can affect people at any age, but they are most common in older people.
Purposeful movements may make the tremors worse. There may be difficulty holding or using small objects (such as eating or writing utensils). Emotional stress may also increase the tremors.
Over time, the tremors may affect the hands, arms, head, voice box (larynx), eyelids, or other muscles, but they rarely involve the legs or feet. In children, these tremors are usually limited to the hands and rarely require treatment.
If you inherit one copy of the gene from either parent, you will have the disorder.
Signs and testsDiagnosis is usually made on the basis of the patient's history and an examination that reveals tremors on voluntary movement with no changes in gait or coordination. There are usually no other abnormalities (such as dementia ) or changes in mental status or brain function.
No other tests may be required. However, testing may be used to rule out other causes of tremors such as excessive caffeine , alcohol withdrawal , medication use, hyperthyroidism , pheochromocytoma , Wilson's disease, or other disorders. Laboratory tests and a head CT scan , MRI , X-rays , angiography , or other tests are usually normal.
TreatmentTreatment may not be necessary unless tremors interfere with the patient's ability to perform daily activities.
Medications are variable because of individual responses to them. Medications that may reduce tremors include propranolol, Mysoline and other anticonvulsants, and mild tranquilizers. If tremors interfere with activity significantly and are not responsive to medication, surgery to implant a deep brain stimulator (DBS) in the basal ganglia may be an option.
Caffeine (in substances such as coffee and soda) and other stimulants should be avoided because they commonly worsen tremors.
Alcoholic beverages in small quantities may markedly decrease tremors, but drinking should be carefully monitored to avoid alcohol abuse and alcohol dependence , especially if there is a family history of alcohol problems. The mechanism by which alcohol ameliorates familial tremor is unknown.
Expectations (prognosis)A familial tremor is not a dangerous condition, but it can be annoying and embarrassing. If it is severe, it can mildly interfere with activities, especially fine-motor skills such as writing. Feeding yourself can be a problem. Speech is occasionally involved.
ComplicationsSide effects of medications may cause complications.
Calling your health care provider
Call your health care provider if tremors occur and there is a family history of tremors or if a familial tremor is interfering with ability to perform daily activities.
Call your health care provider if side effects of medications occur, such as fainting , very slow heart rate , confusion or changes in alertness, or prolonged nausea/vomiting .
Update Date: 7/28/2002Elaine T. Kiriakopoulos, M.D., MSc, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT