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Factor XII (Hageman factor) deficiency


Definition

This is an inherited disorder that causes prolonged clotting (coagulation) of blood in a test tube without a clinical bleeding tendency, and results from a deficiency of the plasma protein factor XII.

Causes, incidence, and risk factors

Factor XII deficiency is a hrare ereditary disorder that is usually found when clotting tests are done for routine screening. It is not associated with abnormal bleeding .

Symptoms

There are usually no symptoms.

Signs and tests

  • Prolonged partial thromboplastin time
  • Abnormal factor XII assay

Treatment

Treatment is generally unnecessary.

Expectations (prognosis)

The outcome is expected to be good without treatment.

Complications

There are usually no complications.

Calling your health care provider

This condition is usually discovered by the health care provider when prolonged clotting is noticed in the process of running other laboratory tests.

Prevention

This is an inherited disorder. There is no known way to prevent it.

Update Date: 8/18/2003

Corey Cutler, M.D., M.P.H., F.R.C.P.C, Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor in Medicine, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT
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