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Factor V deficiency

Alternative names

Parahemophilia; Owren's disease  


Factor V deficiency is an inherited abnormal blood coagulation disorder caused by a deficiency of the plasma protein Factor V.  

Causes, incidence, and risk factors

Normal blood coagulation is a complex process involving as many as 20 different plasma proteins , which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form an insoluble protein called fibrin that stops bleeding .

When certain coagulation factors are deficient or missing, the chain reaction does not take place normally. Factor V deficiency is caused by inheriting a defective Factor V gene. In this disorder, bleeding ranges from mild to severe.

The disease is similar to hemophilia , except bleeding into joints is less common. Bleeding can occur almost anywhere in the body, and death from hemorrhage has occurred with this disorder.

Excessive bleeding with menstrual periods and after delivery occurs frequently. A family history of a bleeding disorder is a risk factor. Men and women are affected equally, and the incidence is about 1 in 1 million.


  • Bleeding into the skin
  • Excessive bruising
  • Nose bleeds
  • Bleeding of the gums
  • Excessive menstrual bleeding
  • Prolonged or excessive loss of blood with surgery or trauma
  • Umbilical stump bleeding

Signs and tests

  • Factor V assay showing decreased activity
  • Slightly prolonged bleeding time (in some people)
  • Prolonged partial thromboplastin time
  • Prolonged prothrombin time
  • Normal thrombin time


Fresh plasma or fresh frozen plasma infusions will correct the deficiency temporarily and should be given daily during a bleeding episode or after surgery.

Support Groups

The stress of illness can often be helped by joining a support group where members share common experiences and problems. See hemophilia - support group.

Expectations (prognosis)

The probable outcome is good with diagnosis and proper treatment.


Severe hemorrhage could occur.

Calling your health care provider

Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.


This is an inherited disorder; there is no known prevention.

Update Date: 5/6/2002

Rebecca Elstrom, M.D., Division of Hematology-Oncology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network (10/14/2001).

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT