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Euglobulin lysis time
This is a test that measures the euglobulin lysis time in blood. The euglobulin lysis time is a measure of the activity of the fibrinolytic (clot-breakdown) system.
How the test is performed
Blood is drawn from a vein ( venipuncture ), usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and a tourniquet (an elastic band) or blood pressure cuff is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the tourniquet to distend (fill with blood). A needle is inserted into the vein, and the blood is collected in an airtight vial or a syringe. During the procedure, the tourniquet is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
Infant or young child:
How to prepare for the test
No special preparation is usually necessary.
Infants and children:
How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis is one of the best tests to differentiate primary fibrinolysis from DIC (disseminated intravascular coagulation) . The test can also be used to monitor streptokinase or urokinase therapy in patients with acute MI (heart attack).
The euglobulin lysis test evaluates fibrinolysis (that is, the dissolution of a blood clot ). The fibrinolytic system normally breaks down small fibrin deposits. When this system is abnormally overactive, any fibrin clot that is formed will be rapidly dissolved, thereby resulting in a bleeding tendency.
Normal ValuesA normal value will range from 90 minutes to 6 hours. Euglobulin clot lysis is normally complete within 2 to 4 hours.
What abnormal results meanIn primary fibrinolysis (for example, caused by streptokinase administration, cancer of the prostate , shock ), the euglobulin lysis time is shorter than normal.
In DIC , it is usually normal, but if all the plasmin has been consumed, the time may be prolonged.
What the risks are
Veins and arteries vary in size from one patient to another, and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Update Date: 5/8/2003Marcia S. Brose, M.D., Ph.D., Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT