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Lomotil overdose

Alternative names

Poisoning from an overdose of Lomotil, an anti-diarrheal, which is a medication comprised of a narcotic agent (opoid derivative) and atropine.

Poisonous Ingredient

  • diphenoxylate
  • atropine

Where Found

  • Lomotil
  • Lofene
  • Logen
  • Lomanate
  • Lonox
Note: This list may not be all inclusive.


  • body as a whole
    • convulsions
  • respiratory
    • slow breathing
    • stopped breathing
  • eyes, ears, nose, and throat
    • pinpoint or dilated pupils
    • nystagmus (rapid side-to-side eye movements)
  • skin
    • flushed skin
  • gastrointestinal
    • constipation
    • nausea
    • vomiting
    • paralytic ileus
  • heart and blood vessels
    • rapid heartbeat
  • nervous system
    • drowsiness
    • coma
    • hallucinations
Note: Symptoms of toxicity may take up to 12 hours to appear.

Home Treatment

Call Poison Control.

Before Calling Emergency

Determine the following:
  • the patient's age, weight, and condition
  • the name of the product (ingredients and strengths if known)
  • the time it was swallowed
  • the amount swallowed
  • it the medication was prescribed for the patient

Poison Control, or a local emergency number

They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room

Some or all of the following procedures may be performed:
  • Induce emesis .
  • Use gastric lavage .
  • Administer activated charcoal.
  • Administer a laxative.
  • Administer a counteracting medication (narcotic antagonist).
  • Children may be kept for observation.

Expectations (prognosis)

After a narcotic antagonist is given, recovery is usually within 24 to 48 hours. Children are at risk of a very poor outcome.

Update Date: 2/12/2004

Cherlin Johnson, M.D., Department of Emergency Medicine, University of Southern California, Los Angeles, CA. Review provided by VeriMed Healthcare Network.

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT