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Creatinine - urine
Alternative namesUrine creatinine - spot collection
DefinitionThe creatinine urine test measures the amount of creatinine in urine.
How the test is performedSpot collection: obtain a sample of urine by urinating and saving part of the urine in a container.
A 24-hour urine sample is needed. The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
This procedure may take a couple of attempts -- lively infants can displace the bag, causing the specimen to be absorbed by the diaper. The infant should be checked frequently and the bag changed after the infant has urinated into the bag. The urine is drained into the container for transport to the laboratory.
How to prepare for the testNo special preparation is necessary for this test, but if the collection is being taken from an infant, a couple of extra collection bags may be necessary.
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performed
A measurement of the serum creatinine level is used to evaluate kidney function. Urine creatinine levels can be used as a screening test to evaluate kidney function, or as part of the creatinine clearance test.
When one of these bonds is broken, energy is released, and ATP becomes ADP. Creatine phosphate represents a backup energy source for ATP because it can quickly re-convert ADP back to ATP.
Normal ValuesNormal values are highly dependent on the age and lean body mass of the person the urine is being collected from. Normal value ranges may vary slightly among different laboratories. Urine creatine (24-hour sample) values may therefore be quite variable and can range from 500 mg/day to 2000 mg/day.
What abnormal results mean
Abnormal results of urine creatinine and creatinine clearance are often non-specific, but may include the following conditions:
What the risks areThere are essentially no risks.
Special considerationsDrugs that can increase creatinine measurements include: aminoglycosides (gentamicin), cimetidine, heavy metal chemotherapeutic agents (Cisplatin), and nephrotoxic drugs, such as cephalosporins (cefoxitin).
Update Date: 2/11/2004Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT