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Alternative namesCoccidioidomycosis antibody test
DefinitionThis test is used to determine the presence of antibodies to the fungus Coccidioides immitis , which causes the disease coccidioidomycosis .
How the test is performed
Blood is drawn from a vein ( venipuncture ), usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and a tourniquet (an elastic band) or blood pressure cuff is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the tourniquet to distend (fill with blood).
A needle is inserted into the vein, and the blood is collected in an airtight vial or a syringe. During the procedure, the tourniquet is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding .
Infant or young child:
Serology refers to the study of serum for its antibody content. An antibody defends the body against bacteria, viruses, fungus, or other foreign bodies (antigens). Certain microbial cells stimulate the body to produce these antibodies during an active infection. Antibody production increases during the course of an infection.
In the initial stage of an illness, few antibodies may be detected. For this reason, serology tests are often repeated several weeks after the initial sample. In the laboratory, the antibodies react with antigens in specific ways that can be used to confirm the identity of a specific microorganism.
There are several serology techniques that can be used depending on the suspected antibodies. Serology techniques include agglutination, precipitation, complement-fixation, and fluorescent antibodies.
How to prepare for the test
There is no special preparation for the test.
Infants and children:
How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThe test detects infection with the fungus Coccidioides immitis , which causes the disease coccidioidomycosis .
Normal ValuesNo precipitation is normal.
What abnormal results meanA complement fixation titer will be performed if the precipitin test is positive. A titer less than 1:16 usually indicates no infection, however titers of 1:2 or 1:4 have been seen in people with active infection. A titer greater than 1:16 usually indicates active infection.
What the risks are
Special considerationsVeins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Update Date: 8/18/2003Daniel Levy, M.D., Ph.D., Infectious Diseases, Greater Baltimore Medical Center, Baltimore, MD. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT