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Alternative namesSomatotroph adenoma; Growth hormone excess
DefinitionAcromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull.
Causes, incidence, and risk factors
Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly.
The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone.
There are no known risk factors for acromegaly other than a prior history of a pituitary tumor.
Signs and tests
This disease may also alter the results of the following tests:
Microsurgery to remove the pituitary tumor causing this condition corrects the abnormal growth hormone secretion in most patients. This surgery may not be available to patients in isolated geographic locations, so travel to a larger metropolitan area may be necessary for treatment.
Pituitary surgery is successful in up to 80% of patients, depending on the size of the tumor and the experience of the surgeon.
Without treatment the symptoms are progressive, and the risk of cardiovascular disease increases.
Calling your health care provider
Call your health care provider if symptoms of acromegaly are present or if symptoms do not improve with treatment.
No measures exist to prevent the initial condition, but early treatment may prevent any worsening of complications associated with this disease.
Update Date: 4/19/2004Nancy J. Rennert, M.D., Endocrinology, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT