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Alternative namesAMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine
DefinitionThis is a test that measures the amount of mucopolysaccharides excreted in the urine over a 24-hour period.
How the test is performedA 24-hour urine sample is needed.
The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
How to prepare for the testNo special preparation is needed. Drink a normal volume of fluids, and consume a normal diet.
How the test will feelThe test involves only normal urination, and there is no discomfort.
Why the test is performedThis test is performed to detect a rare disorder of excess acid mucopolysaccharides accumulation (especially dermatan sulfate and heparan sulfate) in the tissues. The severe form of this disorder can lead to Hurler's syndrome. Typically this test is only ordered for infants where there is a family history of mucopolysaccharidosis .
Normal ValuesNormal acid mucopolysaccharide values vary with age, and the normal range of values varies among laboratories. The laboratory performing the test should be consulted for interpretation of the test result.
What abnormal results meanAbnormally high levels of acid mucopolysaccharides reliably indicate mucopolysaccharidosis, and further detailed studies can identify which enzyme is defective.
What the risks areThere are no risks (except for the chance of inaccurate results if all of the urine is not collected during the 24-hour period).
Special considerationsIf the test was performed on an infant, remove all remaining collection-device adhesive from the skin with warm soap and water.
Update Date: 9/3/2003Michael C. Milone, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT