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Hydroxyurea ( hye-DROX-ee-yoo-REE-ah) belongs to the group of medicines called antimetabolites. It is used to treat some kinds of cancer and to prevent painful episodes associated with sickle cell anemia.
Hydroxyurea seems to interfere with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by hydroxyurea, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
When used in sickle cell anemia, hydroxyurea appears to increase the flexibility of sickled cells.
Before you begin treatment with hydroxyurea, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
Hydroxyurea is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hydroxyurea, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to hydroxyurea.
Pregnancy- Tell your doctor if you are pregnant or if you intend to have children. There is a chance that this medicine may cause birth defects if either the male or female is taking it at the time of conception or if it is taken during pregnancy. Studies have shown that hydroxyurea causes birth defects in animals. In addition, many cancer medicines may cause sterility. Although sterility seems to be only temporary with this medicine, the possibility should be kept in mind.
Be sure that you have discussed this with your doctor before taking this medicine. It is best to use some kind of birth control while you are taking hydroxyurea. Tell your doctor right away if you think you have become pregnant while taking hydroxyurea.
Breast-feeding- Hydroxyurea passes into human breast milk. Tell your doctor if you are breast-feeding or if you intend to breast-feed during treatment with this medicine. Because hydroxyurea may cause serious side effects, breast-feeding is not recommended while you are taking it.
Children- Side effects may be likely to occur in children, who may be more sensitive to the effects of hydroxyurea.
Older adults- Side effects may be more likely to occur in the elderly, who may be more sensitive to the effects of hydroxyurea.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking hydroxyurea, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of hydroxyurea. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Take hydroxyurea only as directed by your doctor . Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.
For patients who cannot swallow the capsules :
This medicine is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the right time and do not mix them. Ask your health care professional to help you plan a way to take your medicine at the right times.
While you are using this medicine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.
This medicine commonly causes nausea, vomiting, and diarrhea. However, it is very important that you continue to use the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.
If you vomit shortly after taking a dose of hydroxyurea, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.
The dose of hydroxyurea will be different for different patients. The dose that is used may depend on a number of things, including what the medicine is being used for, the patient's weight, and whether or not other medicines are also being taken. If you are taking hydroxyurea at home, follow your doctor's orders or the directions on the label . If you have any questions about the proper dose of hydroxyurea, ask your doctor.
If you miss a dose of this medicine, do not take the missed dose at all and do not double the next one. Instead, go back to your regular dosing schedule and check with your doctor.
To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
While you are being treated with hydroxyurea, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval . Hydroxyurea may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Hydroxyurea can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
Side Effects of This Medicine
Side Effects of This Medicine
Along with their needed effects, medicines like hydroxyurea can sometimes cause unwanted effects such as blood problems and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Ask your health care professional for ways to lessen these effects.
Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Hydroxyurea may cause temporary loss of hair in some people. After treatment has ended, normal hair growth should return, although the new hair may be a slightly different color or texture.
After you stop taking hydroxyurea, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor as soon as possible if you notice any of the following side effects:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT