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Dorzolamide and Timolol (Ophthalmic)
In the U.S.-
Dorzolamide (dor-ZOLE-a-mide) and timolol ( TYE-moe-lole) combination medicine contains a carbonic anhydrase inhibitor (dorzolamide) and a beta-adrenergic blocking agent (timolol). It is used in the eye to treat increased pressure in the eye caused by open-angle glaucoma and a condition called hypertension of the eye.
This medicine is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ophthalmic dorzolamide and timolol, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to carbonic anhydrase inhibitors (either ophthalmic or systemic), such as acetazolamide, brinzolamide, dichlorphenamide, dorzolamide, or methazolamide.
In addition, tell your doctor if you have ever had any unusual or allergic reaction to any of the beta-adrenergic blocking agents (either ophthalmic or systemic), such as acebutolol, atenolol, betaxolol, bisoprolol, carteolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, propranolol, sotalol, or timolol.
Also, tell your doctor if you have ever had any unusual or allergic reaction to sulfonamides (sulfa drugs) or thiazide diuretics (a type of water pill).
Furthermore, tell your health care professional if you are allergic to any other substances, such as benzalkonium chloride or other preservatives.
Pregnancy- This medicine has not been studied in pregnant women. However, studies in animals given very high doses of this medicine by mouth have shown that this medicine causes birth defects or other problems. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding- Although it is not known whether dorzolamide passes into the breast milk, timolol has been found to pass into the breast milk and it is possible that it could cause unwanted effects in nursing babies. Mothers who are using this medicine and who wish to breast-feed should discuss this with their doctor.
Children- Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of this medicine in children with use in other age groups.
Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this medicine in the elderly with use in other age groups.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using this medicine, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Use this medicine only as directed by your doctor . Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.
If your doctor ordered two different eye drops to be used together, wait at least 10 minutes between the times you apply the medicines. This will help to keep the second medicine from ****œwashing out" the first one.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
If you miss a dose of this medicine, use it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and is not causing unwanted effects.
If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using this medicine and check with your doctor . These signs may mean that you are allergic to this medicine.
Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine . This medicine contains an ophthalmic beta-adrenergic blocking agent. Using an ophthalmic beta-adrenergic blocking agent during this time may cause an increased risk of side effects.
It is very important that you check with your doctor if you get an injury or infection in your eye or if you are scheduled to have eye surgery. Your doctor will tell you whether to keep using the same container of eye drops or whether you should start using a fresh bottle of eye drops.
For diabetic patients :
This medicine contains benzalkonium chloride, which may be absorbed by contact lenses. Take soft contact lenses out before using this medicine. Lenses may be put back in 15 minutes after using the medicine.
Side Effects of This Medicine
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT