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Probenecid and Colchicine (Systemic)
In the U.S.-
Probenecid and colchicine (proe-BEN-e-sid and KOL-chi-seen) combination is used to treat gout or gouty arthritis.
The probenecid in this medicine helps to prevent gout attacks by removing extra uric acid from the body. The colchicine in this medicine also helps to prevent gout attacks. Although colchicine may also be used to relieve an attack of gout, this requires more colchicine than this combination medicine contains. Probenecid and colchicine combination does not cure gout. This medicine will help prevent gout attacks only as long as you continue to take it.
Probenecid and colchicine combination is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For probenecid and colchicine combination, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to probenecid or to colchicine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Probenecid has not been shown to cause birth defects or other problems in humans. Although studies with colchicine have not been done in pregnant women, some reports have suggested that use of colchicine during pregnancy can cause harm to the fetus. Also, studies in animals have shown that colchicine causes birth defects. Therefore, do not begin taking this medicine during pregnancy, and do not become pregnant while taking it, unless you have first discussed this problem with your doctor. Also, check with your doctor immediately if you suspect that you have become pregnant while taking this medicine.
Breast-feeding- This medicine has not been reported to cause problems in nursing babies.
Children- Studies on this combination medicine have been done only in adult patients, and there is no specific information about its use in children.
Older adults- Elderly people are especially sensitive to the effects of colchicine. This may increase the chance of side effects during treatment.
There is no specific information comparing use of probenecid in the elderly with use in other age groups.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking probenecid and colchicine combination, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of probenecid and colchicine combination. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
If this medicine upsets your stomach, it may be taken with food. If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, loss of appetite, or stomach pain) continues, check with your doctor.
Take this medicine only as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. The colchicine in this combination medicine may cause serious side effects if too much is taken.
After you begin to take this medicine, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. After you have been taking this medicine for several months, they may stop completely.
This medicine will help prevent gout attacks but it will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also .
When you first begin taking this medicine, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones or other kidney problems in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully.
The dose of probenecid and colchicine combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
Your doctor should check your progress at regular visits while you are taking this medicine.
Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by probenecid or by colchicine.
For diabetic patients :
Taking aspirin or other salicylates may lessen the effects of the probenecid in this combination medicine. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking large amounts of alcoholic beverages may increase the chance of stomach problems and may increase the amount of uric acid in your blood. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while you are taking this medicine , unless you have first checked with your doctor.
For patients taking 4 tablets or more of this medicine a day:
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
The following side effects may mean that you are having an allergic reaction to this medicine. Check with your doctor immediately if any of the following side effects occur:
Also check with your doctor immediately if any of the following side effects occur:
Also, check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT