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Chlordiazepoxide and Amitriptyline (Systemic)
In the U.S.-
Chlordiazepoxide and amitriptyline (klor-dy-az-e-POX-ide and a-mee-TRIP-ti-leen ) combination is used to treat mental depression that occurs with anxiety or nervous tension.
This medicine is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For chlordiazepoxide and amitriptyline combination, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to chlordiazepoxide (e.g., Librium) or other benzodiazepines (such as alprazolam [e.g., Xanax], bromazepam [e.g., Lectopam], clonazepam [e.g., Klonopin], clorazepate [e.g., Tranxene], diazepam [e.g., Valium], estazolam [e.g., ProSom], flurazepam [e.g., Dalmane], halazepam [e.g., Paxipam], ketazolam [e.g., Loftran], lorazepam [e.g., Ativan], midazolam [e.g., Versed], nitrazepam [e.g., Mogadon], oxazepam [e.g., Serax], prazepam [e.g., Centrax], quazepam [e.g., Doral], temazepam [e.g., Restoril], triazolam [e.g., Halcion]) or to amitriptyline (e.g., Elavil) or other tricyclic antidepressants (such as amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]).
Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Breast-feeding- Chlordiazepoxide may pass into the breast milk and cause drowsiness, slow heartbeat, shortness of breath, or troubled breathing in babies of mothers taking this medicine. Although amitriptyline has also been found in breast milk, it has not been reported to cause problems in nursing babies.
Children- Children may be especially sensitive to the effects of chlordiazepoxide and amitriptyline combination. This may increase the chance of side effects during treatment.
Older adults- Elderly people are especially sensitive to the effects of chlordiazepoxide and amitriptyline combination. This may increase the chance of side effects during treatment.
Other medicines- Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking chlordiazepoxide and amitriptyline combination, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of chlordiazepoxide and amitriptyline combination. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
To reduce stomach upset, take this medicine immediately after meals or with food unless your doctor has told you to take it on an empty stomach.
Sometimes this medicine must be taken for several weeks before you begin to feel better . Your doctor should check your progress at regular visits.
Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer period of time than your doctor ordered. If too much is taken, it may increase unwanted effects or become habit-forming (causing mental or physical dependence).
If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose . Instead, check with your doctor.
The dose of chlordiazepoxide and amitriptyline combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of chlordiazepoxide and amitriptyline combination. If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking chlordiazepoxide and amitriptyline combination .
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits to allow dose adjustments and help reduce side effects.
Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are using before stopping completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, and/or an overall feeling of discomfort.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine .
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of the metyrapone test may be affected by this medicine.
Before having any surgery, any dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine . Taking chlordiazepoxide and amitriptyline combination together with medicines that are used during surgery or dental or emergency treatments may increase the CNS depressant effects.
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .
Dizziness, lightheadedness, or fainting may occur when you get up from a lying or sitting position . Getting up slowly may help. If this problem continues or gets worse, check with your doctor.
Chlordiazepoxide and amitriptyline combination may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Chlordiazepoxide and amitriptyline combination may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
If you have a severe reaction from the sun, check with your doctor .
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
After you stop using this medicine, your body may need time to adjust . If you took this medicine in high doses or for a long time, this may take up to 2 weeks. During this time check with your doctor if you notice any of the following side effects :
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT