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Other drug names: A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9   

Chloramphenicol (Otic)

Brand Names

In the U.S.-

  • Chloromycetin

In Canada-

  • Chloromycetin

Category

  • Antibacterial, otic

Description

Chloramphenicol (klor-am-FEN-i-kole) belongs to the family of medicines called antibiotics. Chloramphenicol otic drops are used to treat infections of the ear canal. This medicine may be used alone or with other medicines that are taken by mouth for ear canal infections.

Chloramphenicol is available only with your doctor's prescription, in the following dosage form:

    Otic
  • Solution (U.S. and Canada)



Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For chloramphenicol otic, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to chloramphenicol. Also tell your health care professional if you are allergic to any other substances, such as preservatives.

Pregnancy- Chloramphenicol otic solution has not been studied in pregnant women. However, using this medication during pregnancy or labor may increase health risks for the child (See Children ).

Breast-feeding- Chloramphenicol passes into breast milk. Mothers receiving chloramphenicol should not breast-feed their infants.

Children- Gray syndrome may be especially likely to occur in children, who are usually more sensitive than adults to the effects of chloramphenicol. Report any of these effects to your health care professional: blue tone to the skin, changes in blood pressure or heart rate, eating problems, irregular breathing, passage of loose green stools, or stomach bloating with or without vomiting. Your health care professional should monitor blood levels of chloramphenicol if possible.

Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this medicine in the elderly with use in other age groups.

Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine. Chloramphenicol may increase the blood levels of these medications: alfentanil, chlorpropamide, phenobarbital, phenytoin, tolbutamide, and warfarin. Phenobarbital and rifampin may reduce the blood levels of chloramphenicol. Concurrent use of chloramphenicol with vitamin B 12 , folic acid, iron preparations and myelosuppressive agents may inhibit the formation of bone marrow.

Other medical problems- The presence of other medical problems may affect the use of chloramphenicol ear drops. Make sure you tell your doctor if you have any other medical problems, especially:
  • Opening in your ear drum-This medicine may cause unwanted effects if it goes past the ear drum into the middle ear
  • Sensitivity reaction to chloramphenicol


Proper Use of This Medicine

To use:

  • Lie down or tilt the head so that the infected ear faces up. Gently pull the earlobe up and back for adults (down and back for children) to straighten the ear canal. Drop the medicine into the ear canal. Keep the ear facing up for about 1 or 2 minutes to allow the medicine to come into contact with the infection. A sterile cotton plug may be gently inserted into the ear opening to prevent the medicine from leaking out.
  • To keep the medicine as germ-free as possible, do not touch the dropper to any surface (including the ear). Also, keep the container tightly closed.

To help clear up your infection completely, keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses .

Dosing-

The dose of otic chloramphenicol will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of otic chloramphenicol. If your dose is different, do not change it unless your doctor tells you to do so.

  • For otic solution (ear drops) dosage form:
    • For infections of the ear canal:
      • Adults and children-Use 2 or 3 drops in the affected ear two to three times a day.

Missed dose-

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage-

To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Keep the medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.


Precautions While Using This Medicine

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.


Side Effects of This Medicine

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT
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