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Other drug names: A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9   

Opium Preparations (Systemic)

Brand Names


For quick reference, the following opium preparations are numbered to match the corresponding brand names.

Other commonly used names are camphorated opium tincture; laudanum.

This information applies to the following medicines:
1.  Opium Tincture (OH-pee-um TINK-tur)
2.  Paregoric (par-e-GOR-ik)
**  Generic name product may be available in the U.S.
***  Generic name product may be available in Canada
*  Not commercially available in the U.S.
****�  Not commercially available in Canada


  • Antidiarrheal
  • Suppressant, narcotic abstinence syndrome


Opium preparations are used along with other measures to treat severe diarrhea. These medicines belong to the group of medicines called narcotics. If too much of a narcotic is taken, it may become habit-forming, causing mental or physical dependence. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Opium preparations are available only with your doctor's prescription, in the following dosage forms:

  • Opium Tincture
    • Oral liquid (U.S. and Canada)
  • Paregoric
    • Oral liquid (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For opium preparations, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to morphine, codeine, or papaverine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy- Opium preparations have not been studied in pregnant women. However, morphine (contained in these medicines) has caused birth defects in animals when given in very large doses.

Regular use of opium preparations during pregnancy may cause the fetus to become dependent on the medicine. This may lead to withdrawal side effects in the newborn baby. Also, these medicines may cause breathing problems in the newborn baby, especially if they are taken just before delivery.

Breast-feeding- Opium preparations have not been reported to cause problems in nursing babies.

Children- Breathing problems may be especially likely to occur in children up to 2 years of age, who are usually more sensitive than adults to the effects of opium preparations.

Older adults- Breathing problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of opium preparations.

Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking an opium preparation, it is especially important that your health care professional know if you are taking any of the following:

  • Anticholinergics (medicine for abdominal or stomach spasms or cramps) or
  • Central nervous system (CNS) depressants, especially other narcotics, or
  • Other diarrhea medicine or
  • Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])-The chance of side effects is increased
  • Naltrexone (e.g., Trexan)-Naltrexone blocks the effects of opium preparations and makes them less effective in treating diarrhea

Other medical problems- The presence of other medical problems may affect the use of opium preparations. Make sure you tell your doctor if you have any other medical problems, especially:
  • Alcohol or other drug abuse (or history of) or
  • Colitis or
  • Heart disease or
  • Kidney disease or
  • Liver disease or
  • Underactive thyroid-The chance of side effects may be increased
  • Brain disease or head injury or
  • Emphysema, asthma, bronchitis, or other chronic lung disease or
  • Enlarged prostate or problems with urination or
  • Gallbladder disease or gallstones-Some of the side effects of opium preparations can be dangerous if these conditions are present
  • Convulsions (seizures), history of-Opium can rarely cause convulsions

Proper Use of This Medicine

This medicine is to be taken by mouth even if it comes in a dropper bottle. The amount you should take is to be measured with the special dropper provided with your prescription and diluted with water just before you take each dose. This will cause the medicine to turn milky in color, but it will still work.

If your prescription does not come in a dropper bottle and the directions on the bottle say to take it by the teaspoonful, it is not necessary to dilute it before using.

If this medicine upsets your stomach, your doctor may want you to take it with food.

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for young children and for elderly patients, who are especially sensitive to the effects of opium preparations. If too much is taken, this medicine may become habit-forming (causing mental or physical dependence) or lead to problems because of an overdose.


The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

    For opium tincture (laudanum)
  • For oral liquid dosage form (drops):
    • For diarrhea:
      • Adults-5 to 16 drops of liquid, measured with the dropper in the bottle and mixed with a little water, four times a day until diarrhea is controlled.
      • Children-Dose must be determined by your doctor.
    For paregoric
  • For oral liquid dosage form:
    • For diarrhea:
      • Adults-1 or 2 teaspoonfuls one to four times a day until diarrhea is controlled. Use a measuring spoon to measure the dose. An ordinary household teaspoon that is used at the table may not hold the right amount of medicine.
      • Children 2 years of age and older-0.25 to 0.5 milliliters (mL) (4 to 8 drops), mixed with a little water, one to four times a day until diarrhea is controlled. This amount of medicine must be measured with a dropper or a special measuring device that can be used for very small amounts of liquid. If you did not receive a dropper or measuring device with the medicine, check with your pharmacist.

Missed dose-

If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses .


To store this medicine:

  • Keep out of the reach of children. Overdose is very dangerous in young children.
  • Store away from heat and direct light.
  • Keep the container for this medicine tightly closed to prevent the alcohol from evaporating and the medicine from becoming stronger.
  • Do not store this medicine in the refrigerator or allow the medicine to freeze. If it does get cold and you notice any solid particles in it, throw it away.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Check with your doctor if your diarrhea does not stop after 1 or 2 days or if you develop a fever .

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or other narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above, while you are taking this medicine .

This medicine may cause some people to become drowsy, dizzy, lightheaded, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

Dizziness, lightheadedness, or fainting may be especially likely to occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. If you feel very dizzy, lightheaded, or faint after taking this medicine, lying down for a while may help.

If you have been taking this medicine regularly for several weeks or more, do not stop using it without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are using before stopping completely, to lessen the chance of withdrawal side effects.

If you think you or someone else may have taken an overdose, get emergency help at once . Taking an overdose of this medicine or taking alcohol or other CNS depressants with this medicine may lead to unconsciousness and possibly death. Signs of overdose include convulsions (seizures), confusion, severe nervousness or restlessness, severe dizziness, severe drowsiness, slow or irregular breathing, and severe weakness.

Side Effects of This Medicine

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT