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Other drug names: A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9   

Botulinum Toxin Type A (Parenteral-Local)

Brand Names

In the U.S.-

  • Botox

In Canada-

  • Botox


  • Neuromuscular blocking agent, ophthalmic


Botulinum toxin type A (BOT-yoo-lye-num) is used to treat certain eye conditions, such as:

  • Blepharospasm-A condition in which the eyelid will not stay open, because of a spasm of a muscle of the eye.
  • Strabismus-A condition in which the eyes do not line up properly.

Botulinum toxin type A is injected into the surrounding muscle or tissue of the eye, but not into the eye itself. Depending on your condition, more than one treatment may be required.

This medicine is to be administered only by, or under the immediate supervision of, your doctor. It is available in the following dosage form:

  • Injection (U.S. and Canada)

Before Using This Medicine

In deciding to receive a medicine, the risks of receiving the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For botulinum toxin type A, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to botulinum toxin type A. Also tell your health care professional if you are allergic to any other substances.

Pregnancy- Studies on effects in pregnancy have not been done in either humans or animals.

Breast-feeding- It is not known whether botulinum toxin type A passes into the breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children- Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of botulinum toxin type A in children up to 12 years of age with use in other age groups.

Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of botulinum toxin type A in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other ophthalmic prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems- The presence of other medical problems may affect the use of botulinum toxin type A. Make sure you tell your doctor if you have any other medical problems, especially:
  • Heart problems or other medical conditions that may worsen with rapidly increasing activity-Treatment with botulinum toxin type A may give you better vision and the desire to become more active in your daily life; this may put a strain on your heart and body
  • Infection with Clostridium botulinum toxin (botulism poisoning), history of-Persons with a history of infection with Clostridium botulinum toxin (botulism poisoning) may have produced antibodies that may interfere with botulinum toxin type A therapy and make it less effective

Proper Use of This Medicine


The dose of botulinum toxin type A will be different for different patients. The following information includes only the average doses of botulinum toxin type A.

  • For injection dosage form:
    • For certain eye conditions:
      • Adults and children 12 years of age and older-One or more injections into the muscles around the eyes one or more times, depending on the condition being treated.
      • Children up to 12 years of age-Use and dose must be determined by your doctor.

Precautions While Using This Medicine

After you have received this medicine and your vision is better, you may find that you are a lot more active than you were before. You should increase your activities slowly and carefully to allow your heart and body time to get stronger. Also, before you start any exercise program, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur :

  • More common-For blepharospasm
    • Dryness of the eye;  inability to close the eyelid completely 

  • Less common or rare-For blepharospasm
    • Decreased blinking;  irritation of the cornea (colored portion) of the eye;  turning outward or inward of the edge of the eyelid 

Other side effects may occur that usually do not need medical attention. These side effects may go away as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

  • More common-For blepharospasm
    • Blue or purplish bruise on eyelid;  drooping of the upper eyelid;  irritation or watering of the eye;  sensitivity of the eye to light 

  • More common-For horizontal strabismus
    • Drooping of the upper eyelid;  eye pointing upward or downward instead of straight ahead 

  • Less common or rare-For blepharospasm or strabismus
    • Skin rash;  swelling of the eyelid skin  

  • Less common or rare-For horizontal strabismus
    • Difficulty finding the location of objects;  double vision 

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Additional Information

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, botulinum toxin type A is used in certain patients with the following medical conditions:

  • Deep facial lines or wrinkles
  • Frey's syndrome (gustatory sweating) (red area and sweating on the cheek while eating)
  • Hyperhidrosis (severe sweating of the palms and armpits)
  • Spasms of the arms, feet, hands, or legs caused by brain injury, multiple sclerosis, spinal cord injury, or stroke
  • Spasms of the arms and legs in children with cerebral palsy
  • Spasms of the face
  • Spasms of the hand, including writer's cramp and musician's cramp
  • Spasms of the neck
  • Spasms of the vocal cords

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT