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Rh o(D) Immune Globulin (Systemic)

Brand Names

In the U.S.-

  • BayRho-D Full Dose
  • BayRho-D Mini-Dose
  • RhoGAM
  • WinRho SDF

In Canada-

  • BayRho-D Full Dose
  • WinRho SDF

Other commonly used names are anti-D gammaglobulin; anti-D (Rh o) immunoglobulin; anti-Rh immunoglobulin; anti-Rh o(D); D(Rh o) immune globulin; RhD immune globulin; Rh immune globulin; Rh-IG; Rh o(D) immune human globulin.


  • Immunizing agent, passive
  • platelet count stimulator (systemic)


Rh o (D) immune globulin is used to prevent your body from interacting with any of your baby's blood that may get into your blood system while you are pregnant or during the delivery of your baby. If your blood type is Rh o (D) negative and your baby's blood type is Rh o (D) positive, your body may produce a defense (antibodies) against Rh o (D) positive blood. These antibodies usually will not cause a problem if this is your first pregnancy, unless you have had a blood transfusion in the past and have already developed these antibodies. However, if you have other Rh o (D) positive babies in the future, these antibodies may try to destroy the blood of the future babies. If this occurs, it is a very serious condition. Babies born with this condition may need to have their blood replaced.

Rh o (D) immune globulin can be used to treat immune thrombocytopenic purpura, a type of blood disorder. This medicine may be helpful to prevent excessive bleeding.

Rh o (D) immune globulin may also be used if you have recently received a transfusion that contained Rh o (D) positive blood and your blood type is Rh o (D) negative.

Rh o (D) immune globulin is to be administered only by or under the supervision of your doctor or other health care professional. It is available in the following dosage form:

  • Injection (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Rh o (D) immune globulin, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to Rh o (D) immune globulin or any other kind of human immune globulin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy- Studies on effects in pregnancy have not been done in either humans or animals. However, this medicine has been used in pregnant women and has not been shown to cause birth defects or other problems.

Breast-feeding- Rh o (D) immune globulin has not been reported to cause problems in nursing babies.

Children- Studies on this medicine have been done only in adult patients and there is no specific information comparing use of Rh o (D) immune globulin in children with use in other age groups.

Other medical problems- The presence of other medical problems may affect the use of Rh o (D) immune globulin. Make sure you tell your doctor if you have any other medical problems, especially:
  • Immunoglobulin A (IgA) deficiencies-Rh o (D) immune globulin may cause an allergic reaction to occur
  • Rh o (D) positive patients with immune thrombocytopenic purpura, ITP (a type of blood disorder)-Should be monitored for anemia and kidney problems

Proper Use of This Medicine


The dose of Rh o (D) immune globulin will be different for different patients. The following information includes only the average dose of Rh o (D) immune globulin.

  • For injection dosage form:
    • To prevent your body from producing antibodies against Rh o (D) positive blood:
      • Adults and children-One or more injections, depending on how much Rh o (D) positive blood has gotten into your blood system. The medicine may be used during your pregnancy, within 72 hours after your baby is born, at the end of an incomplete pregnancy (abortion, miscarriage), or after a transfusion. The medicine is usually injected into a muscle, although it may be injected into a vein.
    • To help prevent excessive bleeding in patients with immune thrombocytopenic purpura, ITP (a type of blood disorder):
      • Adults and children-One or more injections, depending on factors in your blood. The medicine is injected into a vein.

Side Effects of This Medicine

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor if any of the following side effects occur:

  • Rare
    • Bloody urine;  decreased frequency of urination or amount of urine;  increased blood pressure ;  increased thirst;  loss of appetite;  lower back pain;  nausea or vomiting;  pale skin;  swelling of face, fingers, or lower legs;  troubled breathing;  unusual bleeding or bruising;  unusual tiredness or weakness;  weight gain 

The following side effects may occur and usually do not need medical attention. However, check with your doctor if either of the following side effects continue or are bothersome:

  • Less common
    • Fever;  soreness at the place of injection  

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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Last updated: Tue, 06 Jan 2009 00:20:03 GMT