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Other commonly used names are 2-PAM; 2-PAM chloride.
Pralidoxime ( pra-li-DOX-eem) is used together with another medicine called atropine to treat poisoning caused by organic phosphorus pesticides (e.g., diazinon, malathion, mevinphos, parathion, and sarin) and by organophosphate chemicals (****œnerve gases") used in chemical warfare. Pralidoxime is also used to treat overdose of medicines, such as ambenonium, neostigmine, and pyridostigmine, that are used to treat myasthenia gravis. Poisoning with these chemicals or medicines causes your muscles, including the muscles that help you breathe, to become weak. Pralidoxime is used to help you get back strength in your muscles.
Pralidoxime is to be given only by or under the direct supervision of a doctor or trained military personnel. It is available in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pralidoxime, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to pralidoxime. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Studies on effects in pregnancy have not been done in either humans or animals.
Breast-feeding- It is not known whether pralidoxime passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.
Children- Although there is no specific information comparing use of pralidoxime in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
Older adults- Many medicines have not been studied specifically in older people. Therefore it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no information comparing use of pralidoxime in the elderly with use in other age groups.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using pralidoxime, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of pralidoxime. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
For patients using the pralidoxime auto-injector (automatic injection device):
Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor or medic ordered . Do not use more than recommended on the label unless otherwise directed by your doctor or medic.
The dose of pralidoxime will be different for different patients. Follow your doctor's or medic's orders or the directions on the label . The following information includes only the average doses of pralidoxime.
To store this medicine:
Precautions While Using This Medicine
This medicine will add to the effects of CNS depressants (medicines that may make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, pralidoxime has been used in some patients to treat poisoning caused by certain carbamate pesticides.
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT