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Other drug names: A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9   

Sulfinpyrazone (Systemic)

Brand Names

In the U.S.-

  • Anturane

In Canada-

  • Anturan
  • Apo-Sulfinpyrazone
  • Novopyrazone

Category

  • Antigout agent
  • Antihyperuricemic

Description

Sulfinpyrazone (sul-fin-PEER-a-zone ) is used in the treatment of chronic gout (gouty arthritis), which is caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Sulfinpyrazone does not cure gout, but after you have been taking it for a few months it may help prevent gout attacks. This medicine will help prevent gout attacks only as long as you continue to take it.

Sulfinpyrazone is sometimes used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Sulfinpyrazone may also be used for other conditions as determined by your doctor.

Sulfinpyrazone is available only with your doctor's prescription, in the following dosage forms:

    Oral
  • Capsules (U.S.)
  • Tablets (U.S. and Canada)



Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sulfinpyrazone, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to sulfinpyrazone or to aspirin, oxyphenbutazone (e.g., Tandearil), or phenylbutazone (e.g., Butazolidin), or other anti-inflammatory analgesics (medicines used for pain and/or inflammation). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy- Sulfinpyrazone has not been reported to cause problems in humans.

Breast-feeding- It is not known whether sulfinpyrazone passes into the breast milk.

Children- Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of sulfinpyrazone in children with use in other age groups.

Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of sulfinpyrazone in the elderly with use in other age groups.

Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sulfinpyrazone, it is especially important that your health care professional know if you are taking any of the following:

  • Anticoagulants (blood thinners) or
  • Carbenicillin by injection (e.g., Geopen) or
  • Cefamandole (e.g., Mandol) or
  • Cefoperazone (e.g., Cefobid) or
  • Cefotetan (e.g., Cefotan) or
  • Dipyridamole (e.g., Persantine) or
  • Divalproex (e.g., Depakote) or
  • Heparin (e.g., Panheprin) or
  • Inflammation or pain medicine, except narcotics, or
  • Moxalactam (e.g., Moxam) or
  • Pentoxifylline (e.g., Trental) or
  • Plicamycin (e.g., Mithracin) or
  • Ticarcillin (e.g., Ticar) or
  • Valproic acid (e.g., Depakene)-Use of these medicines together with sulfinpyrazone may increase the chance of bleeding
  • Antineoplastics (cancer medicine)-The chance of serious side effects may be increased
  • Aspirin or other salicylates, including bismuth subsalicylate (e.g., Pepto Bismol)-These medicines may keep sulfinpyrazone from working properly in treating gout, depending on the amount of aspirin or other salicylate that you take and how often you take it. Taking sulfinpyrazone and aspirin together may also increase the chance of bleeding
  • Nitrofurantoin (e.g., Furadantin)-Sulfinpyrazone may keep nitrofurantoin from working properly

Other medical problems- The presence of other medical problems may affect the use of sulfinpyrazone. Make sure you tell your doctor if you have any other medical problems, especially:
  • Blood disease (or history of) or
  • Cancer being treated by antineoplastics (cancer medicine) or radiation (x-rays) or
  • Kidney stones (or history of) or other kidney disease or
  • Stomach ulcer or other stomach or intestinal problems (or history of)-The chance of serious side effects may be increased; also, sulfinpyrazone may not work properly for treating gout if some kinds of kidney disease are present


Proper Use of This Medicine

If sulfinpyrazone upsets your stomach, it may be taken with food . If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, or stomach pain) continues, check with your doctor.

In order for sulfinpyrazone to help you, it must be taken regularly as ordered by your doctor .

When you first begin taking sulfinpyrazone, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully .

For patients taking sulfinpyrazone for gout :

  • After you begin to take sulfinpyrazone, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful. After you have been taking sulfinpyrazone for several months, they may stop completely.
  • Sulfinpyrazone helps to prevent gout attacks. It will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also .

Dosing-

The dose of sulfinpyrazone will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of sulfinpyrazone. If your dose is different, do not change it unless your doctor tells you to do so.

  • For treating gout or removing uric acid from the body :
    • Adults: The starting dose of sulfinpyrazone is usually 100 mg or 200 mg a day (one-half of a 100-mg tablet two times a day, one 100-mg tablet one or two times a day, or one 200-mg capsule or tablet once a day). Then, the dose is usually increased by 100 mg or 200 mg every few days, up to 800 mg a day. Starting with a low dose and increasing the dose gradually helps prevent kidney stones and other side effects. After a while, the dose may be changed again, depending on the amount of uric acid in your blood or urine.
    • Children: It is not likely that sulfinpyrazone will be needed to treat gout or remove uric acid from the body in children. However, if a child needs this medicine, the dose would have to be determined by the doctor.

Missed dose-

If you miss a dose of this medicine, take it as soon as possible. However, if is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage-

To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.


Precautions While Using This Medicine

Your doctor should check your progress at regular visits to make sure that this medicine does not cause unwanted effects.

Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by sulfinpyrazone.

For patients taking sulfinpyrazone for gout or to help remove uric acid from the body :

  • Taking aspirin or other salicylates may lessen the effects of sulfinpyrazone. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of sulfinpyrazone. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking this medicine , unless you have first checked with your doctor.


Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

  • Rare
    • Shortness of breath, troubled breathing, tightness in chest, and/or wheezing;  sores, ulcers, or white spots on lips or in mouth;  sore throat and fever with or without chills;  swollen and/or painful glands;  unusual bleeding or bruising 

  • Symptoms of overdose
    • Clumsiness or unsteadiness;  convulsions (seizures);  diarrhea;  nausea or vomiting (severe or continuing);  stomach pain (severe or continuing);  difficulty in breathing 

Also, check with your doctor as soon as possible if any of the following side effects occur:

  • More common
    • Lower back and/or side pain;  painful urination (possibly with blood) 

  • Less common
    • Skin rash 

  • Rare
    • Bloody or black, tarry stools;  fever ;  increased blood pressure;  pinpoint red spots on skin;  sudden decrease in amount of urine;  swelling of face, fingers, feet, and/or lower legs;  unusual tiredness or weakness;  vomiting of blood or material that looks like coffee grounds ;  weight gain 

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

  • More common
    • Joint pain, redness, and/or swelling;  nausea or vomiting;  stomach pain 

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.



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Last updated: Tue, 06 Jan 2009 00:20:03 GMT
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