Please be patient! It may take up to ONE minute to load all the Engines.
Problems? Please contact our support.
In the U.S.-
Nitisinone (ni-TIS-uh-none) is given along with a special diet to treat hereditary tyrosinemia, type 1. This disease is caused by too much tyrosine in the blood. It may cause damage to the liver, kidneys, eyes, skin, and nervous system. Treatment with nitisinone and diet may slow the disease, but it will not cure it.
This medicine is available only with your or your child's doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nitisinone, the following should be considered:
Allergies- Tell your doctor if you or your child have ever had any unusual or allergic reaction to nitisinone. Also tell your doctor and pharmacist if you or your child is allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Nitisinone has not been studied in pregnant women. However, studies in rats have shown that nitisinone causes reduced litter size, low birth weight and decreased survival after birth. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding- It is not known whether nitisinone passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.
Children- This medicine has been tested in children and, in effective doses, has not been shown to cause specific problems.
Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of nitisinone in the elderly with use in other age groups.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you or your child is taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Proper Use of This Medicine
To use :
The dose of nitisinone will be different for different patients. Follow your doctor's orders or the directions on the label .
The number of capsules that you or your child takes depends on the strength of the medicine.
If a dose of this medicine is missed, take it as soon as possible. However, if it is almost time, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
While taking this medicine, it is important that you or your child maintain a diet with restricted amounts of tyrosine and phenylalanine A nutritionist may be able to help you with the special diet needed to treat you. A nutritionist that has special training with children may help with a diet for your child.
Call your doctor right away for any redness, swelling, or burning of your or your child's eyes, an unusual rash, bleeding, or if your or your child's skin is yellow.
It is very important that the doctor check you or your child at regular visits to see how the medicine is working and increase the dose if needed. The doctor may test your your child's blood often.
A special examination of your or your child's eyes should be done before this medicine is started.
Wearing sunglasses that block ultraviolet light is recommended. Nitisinone may cause sensitivity of the eyes to the sunlight.
Side Effects of This Medicine
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with the doctor immediately if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as the body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT