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Nafarelin (NAF-a-re-lin ) is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used in the treatment of:
When given regularly to boys and girls, this medicine helps to prevent them from continuing to develop the sexual features associated with puberty, slowing down the development of breasts in girls and the development of genital areas in boys and girls. This medicine delays puberty in a child only as long as the child continues to take it.
Nafarelin prevents the growth of tissue associated with endometriosis in adult women during treatment and for 6 months after treatment is discontinued. Reducing the amount of estrogen in the body is one way of treating endometriosis.
Suppressing estrogen can thin the bones or slow their growth. This is a problem for adult women whose bones are no longer growing like the bones of children. Slowing the growth of bones is a positive effect for girls and boys whose bones grow too fast when puberty begins too early. This is why nafarelin is used only for up to 6 months in adult women treated for endometriosis, but often is used for a longer time in girls and boys with pubertal problems. Boys and girls may benefit by adding inches to their adult height when nafarelin causes their bones to grow at a proper rate.
Nafarelin is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nafarelin, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to nafarelin or to gonadotropin-releasing hormone****“like medicines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Nafarelin use is not recommended during pregnancy. Nafarelin has not been studied in pregnant women. It has been shown to cause problems in animals, such as low birth weights and a slight decrease in the number of successful pregnancies.
For treatment of endometriosis - Stop taking this medicine immediately and check with your doctor if you suspect that you may have become pregnant .
Breast-feeding- It is not known whether nafarelin passes into the breast milk. However, use of nafarelin is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
Children- Studies of this medicine for treatment of endometriosis have been done only in adult patients, and there is no specific information comparing use of nafarelin to treat this condition in children younger than 18 years of age with use in other age groups. Endometriosis is not likely to occur before puberty.
When used to treat a child for central precocious puberty, nafarelin will stop having an effect soon after the child stops using it, and puberty will advance normally. It is not known if nafarelin causes:
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nafarelin, it is especially important that your health care professional know if you are taking the following:
Other medical problems- The presence of other medical problems may affect the use of nafarelin. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
You will be given a fact sheet with your prescription for nafarelin that explains how to use the pump spray bottle. If you have any questions about using the pump spray, ask your health care professional.
To use nafarelin spray :
It is important to avoid sneezing when spraying and immediately after using the medicine. If you sneeze, the medicine may not be absorbed as well.
Use this medicine only as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Using too much may increase the chance of side effects, while using too little may not improve your condition.
Many boys and girls who have central precocious puberty will not feel sick or will not understand the importance of taking the medicine regularly. It is very important that the medicine is used exactly as directed and that the proper amount is used at the proper time. It works best when there is a constant amount in the blood. To help keep the amount constant, nafarelin must be given on a regular schedule.
The dose of nafarelin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average dose of nafarelin. If your dose is different, do not change it unless your doctor tells you to do so.
If you miss a dose of this medicine, take it as soon as possible. However, if you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
All scheduled visits to the doctor should be kept, even if the medicine seems to be working properly and you feel well. This is especially important for children using the medicine for treatment of central precocious puberty, even if their condition improves. Their progress still must be checked by the doctor when they are no longer using the medicine.
For children treated for central precocious puberty- Tell the doctor if nafarelin does not stop puberty from progressing within 6 to 8 weeks. You may notice puberty progressing in your child for the first few weeks of therapy, but you should see signs that puberty is stopping within 4 weeks after your child begins nafarelin therapy.
For adult women treated for endometriosis -
Side Effects of This Medicine
In the first few weeks of therapy, you may notice puberty progressing in your child, including vaginal bleeding and breast enlargement in girls. Within 4 weeks after nafarelin has had time to begin working properly, you should see signs in boys and girls that puberty is stopping. However, pubic hair may continue to show or grow in either boys or girls.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. Some of these side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT