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Metyrapone ( me-TEER-a-pone) is used in the diagnosis of certain problems of the adrenal glands. These glands are located near the kidneys. The adrenal glands produce a steroid chemical called cortisol (hydrocortisone) that helps the body respond to stress or illness. From the results of a metyrapone test, your doctor will be able to tell if your adrenal glands produce the correct amount of cortisol under stress or during illnesses.
How test is done: Metyrapone is taken by mouth in one or more doses the day before the testing is done. The next day, blood and/or urine samples are taken. A tube called a catheter may be placed in your bladder to help take the urine sample. The amount of hormones in your blood or urine is measured. Then the results of the test are studied.
Metyrapone may also be used for other conditions as determined by your doctor.
Metyrapone is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For metyrapone, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to metyrapone. Also, tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Metyrapone has not been fully studied in pregnant women. However, some small studies have shown that metyrapone can affect the production of chemicals by the pituitary and adrenal glands of the fetus. Also, the large amounts of estrogen produced by your body during pregnancy may cause false results in metyrapone testing. Before you take metyrapone, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding- It is not known whether metyrapone passes into the breast milk. However, use of metyrapone is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
Children- This medicine has been tested in children and has not been shown to cause different side effects or problems in children than it does in adults.
Older adults- Although there is no specific information about the use of metyrapone in the elderly, it is not expected to cause different side effects or problems in older people than it does in younger adults.
Other medicines- Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking metyrapone, it is especially important that your health care professional know if you are also taking any other medicines, since many medicines can cause false results in metyrapone testing. This may result in a wrong diagnosis. It is especially important that your doctor know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of metyrapone. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Metyrapone may cause nausea and vomiting, especially if taken in larger doses. Taking each dose with food or milk or immediately after eating may lessen this effect.
Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
The dose of metyrapone will be different for different patients. Follow your doctor's orders . The dose will be given by your doctor. The following information includes only the average doses of metyrapone.
If you are taking metyrapone every day to treat Cushing's syndrome and you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you are taking metyrapone for a test procedure and you miss a dose, contact your physician. Missing doses or taking them on the wrong schedule may cause false test results.
To store this medicine:
Precautions While Using This Medicine
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, metyrapone is used in certain patients with the following medical condition:
Since treatment for Cushing's syndrome may require longer therapy, side effects are more likely to occur.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT