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Antithyroid Agents (Systemic)
Another commonly used name for methimazole is thiamazole.
Methimazole and propylthiouracil are used to treat conditions in which the thyroid gland produces too much thyroid hormone.
These medicines work by making it harder for the body to use iodine to make thyroid hormone. They do not block the effects of thyroid hormone that was made by the body before their use was begun.
Methimazole and propylthiouracil are available only with your doctor's prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For antithyroid agents, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to methimazole or propylthiouracil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Use of too large a dose during pregnancy may cause problems in the fetus. However, use of the proper dose, with careful monitoring by the doctor, is not likely to cause problems.
Breast-feeding- These medicines pass into breast milk. (Methimazole passes into breast milk more freely and in higher amounts than propylthiouracil.) However, your doctor may allow you to continue to breast-feed, if your dose is low and the infant gets frequent check-ups. If you are taking a large dose, it may be necessary for you to stop breast-feeding during treatment.
Children- This medicine has been used in children and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults.Teenagers- This medicine has been used in teenagers and, in effective doses, has not been shown to cause different side effects or problems in teenagers than it does in adults.
Older adults- Elderly people may have an increased chance of certain side effects during treatment. Your doctor may need to take special precautions while you are taking this medicine.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking antithyroid agents, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of antithyroid agents. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Use this medicine only as directed by your doctor . Do not use more or less of it and do not use it more often or for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, if you are taking more than one dose a day, it is best to take the doses at evenly spaced times day and night . For example, if you are to take 3 doses a day, the doses should be spaced about 8 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
Food in your stomach may change the amount of methimazole that is able to enter the bloodstream. To make sure that you always get the same effects, try to take methimazole at the same time in relation to meals every day. That is, always take it with meals or always take it on an empty stomach.
The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets that you take or the number of suppositories that you use depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking antithyroid agents .
If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, take both doses together. Then go back to your regular dosing schedule. If you miss more than one dose or if you have any questions about this, check with your doctor.
To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
It may take several days or weeks for this medicine to work. However, do not stop taking this medicine without first checking with your doctor . Some medical problems may require several years of continuous treatment.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine .
Check with your doctor right away if you get an injury, infection, or illness of any kind . Your doctor may want you to stop taking this medicine or change the amount you are taking.
While you are being treated with antithyroid agents, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval . Antithyroid agents may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Side Effects of This Medicine
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT