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Another commonly used name is RO 11****“1163.
Moclobemide ( moe-KLOE-be-mide)
is a monoamine oxidase (MAO) inhibitor used to relieve certain types of mental depression. It works by blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system.
Although this medicine is very effective for certain patients, it may also cause some unwanted reactions if not taken in the right way. It is very important to avoid certain beverages and medicines while you are being treated with an MAO inhibitor. Your doctor may provide a list as a reminder of which products you should avoid.
This medicine is available only with your doctor's prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For moclobemide, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to moclobemide or monoamine oxidase inhibitors. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Studies of moclobemide use in pregnant women have not been done. In some animal studies, weight gain was decreased in pregnant females or their offspring after high doses of moclobemide. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding- Small quantities of moclobemide pass into the breast milk. Moclobemide is not recommended during breast-feeding, because it may cause unwanted effects in nursing babies.
Children- Studies on moclobemide have been done only in adult patients, and there is no specific information comparing use of moclobemide in children with use in other age groups.
Older adults- Older adults are especially sensitive to the effects of moclobemide. This may increase the chance of side effects during treatment. Dizziness or lightheadedness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to these effects.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking moclobemide, it is especially important that your doctor and pharmacist know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of moclobemide. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Sometimes this medicine must be taken for several weeks before you begin to feel better. Your doctor should check your progress at regular visits, especially during the first few months of treatment, to make sure that this medicine is working properly and to check for unwanted effects .
Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Moclobemide should be taken after a meal. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.
The dose of moclobemide will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of moclobemide. If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking moclobemide .
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
When taken with certain drinks or other medicines, moclobemide and other monoamine oxidase inhibitors can cause very dangerous reactions such as sudden high blood pressure (also called hypertensive crisis). To avoid such reactions, obey the following rules of caution :
Check with your doctor immediately if you experience any combination of the following symptoms: severe throbbing headache which starts at the back of the head and radiates forward, stiff neck, fast or racing heartbeat, pounding or irregular heartbeat, or slow heartbeat. These may be symptoms of a serious side effect that should have a doctor's attention.
Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are using before stopping completely.
Dizziness, lightheadedness, or fainting may occur , especially when you get up from a lying or sitting position. Getting up slowly may help . When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes. Then stand up slowly. If the problem continues or gets worse, check with your doctor.
This medicine may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are unable to see well or are not alert .
Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine or have used it within the past 2 weeks . Taking moclobemide together with medicines that are used during surgery or dental or emergency treatments may increase the risk of serious side effects.
After you stop using this medicine, you must continue to exercise caution for at least 1 to 2 weeks concerning drink and other medicine, since these things may continue to react with moclobemide.
Side Effects of This Medicine
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Stop taking this medicine and check with your doctor immediately if any combination of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT