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In the U.S.-
Loxapine ( LOX-a-peen) is used to treat nervous, mental, and emotional conditions.
Loxapine is available only with your doctor's prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For loxapine, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to loxapine or amoxapine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Loxapine has not been shown to cause birth defects or other problems in humans. However, animal studies have shown unwanted effects in the fetus.
Breast-feeding- It is not known if loxapine passes into breast milk.
Children- Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of loxapine in children with use in other age groups.
Older adults- Elderly patients are usually more sensitive than younger adults to the effects of loxapine. Constipation, dizziness or fainting, drowsiness, dry mouth, trembling of the hands and fingers, and symptoms of tardive dyskinesia (such as rapid, worm-like movements of the tongue or any other uncontrolled movements of the mouth, tongue, or jaw, and/or arms and legs) are especially likely to occur in elderly patients.
Other medicines- Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking loxapine, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems- The presence of other medical problems may affect the use of loxapine. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
This medicine may be taken with food or a full glass (8 ounces) of water or milk to reduce stomach irritation.
For patients taking the oral solution :
The liquid medicine must be mixed with orange juice or grapefruit juice just before you take it to make it easier to take.
Do not take more of this medicine, do not take it more often, and do not take it for a longer time than your doctor ordered . To do so may increase the chance of unwanted effects.
The dose of loxapine will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of loxapine. If your dose is different, do not change it unless your doctor tells you to do so.
The number of capsules or tablets or amount of solution that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking loxapine .
If you miss a dose of this medicine, take it as soon as possible. However, if it is within one hour of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
To store this medicine:
Precautions While Using This Medicine
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of loxapine you take may be changed often to meet the needs of your condition and to help avoid side effects.
Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to reduce gradually the amount you are taking before stopping completely. This will allow your body time to adjust and to keep your condition from becoming worse.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine .
Do not take this medicine within two hours of taking antacids or medicine for diarrhea. Taking loxapine and antacids or medicine for diarrhea too close together may make this medicine less effective.
This medicine may cause some people to become drowsy or less alert than they are normally, especially as the amount of medicine is increased. Even if you take this medicine at bedtime, you may feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert .
Although it is not a problem for most patients, dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. However, if the problem continues or gets worse, check with your doctor.
Loxapine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
If you have a severe reaction from the sun, check with your doctor .
Loxapine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine . Taking loxapine together with medicines that are used during surgery or dental or emergency treatments may increase the CNS depressant effects.
Side Effects of This Medicine
Along with its needed effects, loxapine can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it .
Stop taking loxapine and get emergency help immediately if any of the following side effects occur:
Check with your doctor immediately if any of the following side effects occur:
Also, check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Certain side effects of this medicine may occur after you have stopped taking it. Check with your doctor as soon as possible if you notice any of the following effects after you have stopped taking loxapine:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, loxapine is used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT