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Another commonly used name is leuprorelin.
Leuprolide (loo-PROE-lide) may be used for a number of different medical problems. These include treatment of:
Leuprolide is similar to a hormone normally released from the hypothalamus gland.
When given regularly to men and boys, leuprolide decreases testosterone levels. Reducing the amount of testosterone in the body is one way of treating cancer of the prostate.
When given regularly to women and girls, leuprolide decreases estrogen levels. Reducing the amount of estrogen in the body is one way of treating endometriosis. By shrinking tumors in the uterus, leuprolide helps stop anemia by decreasing the vaginal bleeding from these tumors. Iron supplements should be used to help treat the anemia.
When given to boys and girls experiencing early puberty, leuprolide slows down the development of the genital areas in both sexes and breast development in girls. This medicine delays puberty in a child only as long as the child continues to receive it.
Suppressing estrogen can cause thinning of the bones or slowing of their growth. This is a problem for adult women whose bones are no longer growing like the bones of children. Slowing the growth of bones is a positive effect in girls and boys whose bones grow too fast when puberty begins too early. Boys and girls may benefit by adding inches to their adult height when leuprolide helps their bones grow at the proper and expected rate for children.
Leuprolide is available only with your doctor's prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For leuprolide, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to leuprolide, buserelin, gonadorelin, histrelin, nafarelin, or to benzyl alcohol, a preservative present in some of the leuprolide products.
Pregnancy- Tell your doctor if you intend to have children.
Breast-feeding- It is not known whether leuprolide passes into breast milk. However, use of leuprolide is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
Children- Leuprolide will stop having an effect on a child treated for central precocious puberty soon after the child stops using it, and puberty will advance normally. It is not known if using leuprolide around the time of puberty causes changes in boys' and girls' future abilities to have babies. Their chances of having children later are thought to be normal. It is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.
Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of leuprolide in the elderly to use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.
Other medicines- Although certain medicines should not be used together at all, in other cases two medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your doctor and pharmacist if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems- The presence of other medical problems may affect the use of leuprolide. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Leuprolide comes with patient directions. Read these instructions carefully .
Use the syringes provided in the kit. Other syringes may not provide the correct dose. These disposable syringes and needles are already sterilized and are designed to be used one time only and then discarded. If you have any questions about the use of disposable syringes, check with your health care professional.
Use this medicine only as directed by your doctor . Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Using too much may increase the chance of side effects, while using too little may not improve your condition.
For adult patients receiving leuprolide for anemia caused by tumors of the uterus or for endometriosis :
For adult patients receiving leuprolide for cancer of the prostate :
The dose of leuprolide will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of leuprolide. If your dose is different, do not change it unless your doctor tells you to do so:
If you are using this medicine every day and you miss a dose, give it as soon as possible. However, if you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you are using this medicine once a month or every 3 to 12 months and you miss a dose, receive it as soon as possible, and go back to your regular dosing schedule.
To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
For patients receiving leuprolide for endometriosis or for anemia caused by tumors of the uterus :
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Get emergency help immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, leuprolide is used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT