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Amprenavir (Am-PREN-a-veer ) is a protease inhibitor. It is used in combination with other medicines to treat patients who are infected with the human immunodeficiency virus (HIV).
HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Amprenavir may slow down the destruction of the immune system caused by HIV. This may help delay the development of problems usually related to AIDS or HIV disease. However, this medicine will not cure or prevent HIV infection, and it will not keep you from spreading the virus to other people. Patients who are taking this medicine may continue to have the problems usually related to AIDS or HIV disease.
This medicine is available only with your doctor's prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amprenavir, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to amprenavir or sulfa medicines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Amprenavir has not been studied in pregnant women. However, studies in animals have shown that amprenavir causes birth defects and other problems. Amprenavir capsules should only be used during pregnancy if the benefit outweighs the potential risk.Amprenavir capsules should only be used during pregnancy if the benefit outweighs the potential risk. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding- It is not known whether amprenavir passes into breast milk. However, breast-feeding is not recommended in patients with HIV-infection because of the risk of passing the HIV virus on to the nursing infant.Mothers should not breast-feed while taking amprenavir.
Children- This medicine has been tested in children 4 years of age and older. In effective doses, the medicine has not been shown to cause different side effects or problems than it does in adults.
Older adults- Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. However, specific side effects may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of amprenavir.There is no specific information comparing use of amprenavir in the elderly with use in other age groups.
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking amprenavir, it is especially important that your health care professional know if you are taking any other medicines (prescription or over-the-counter [OTC], especially the following:
Other medical problems- The presence of other medical problems may affect the use of amprenavir. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Amprenavir may be taken with or without food. However, it should not be taken with a high-fat meal. Taking amprenavir with a high-fat meal may decrease the amount of amprenavir that is absorbed by the body and prevent the medicine from working properly.
You should not drink alcoholic beverages while you are taking the oral solution form of this medicine.
It is important to take amprenavir as part of a combination treatment. Your dose of medicine will be based on what other medicines you are taking, as well as your weight. Be sure to take all the medicines your doctor has prescribed for you, including amprenavir.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.
Keep taking amprenavir for the full time of treatment, even if you begin to feel better.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If you need help in planning the best times to take your medicine, check with your health care professional.
Only take medicine that your doctor has prescribed especially for you. Do not share your medicine with others.
The dose of amprenavir will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of amprenavir. If your dose is different, do not change it unless your doctor tells you to do so.
The number of capsules or teaspoonfuls of solution that you take depends on the strength of the medicine.
If you are taking amprenavir capsules and you miss a dose , take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you are taking amprenavir oral solution and you miss a dose, if it has been less than 4 hours since the dose was missed, take it immediately and then go back to your regular dosing schedule. If it has been more than 4 hours since the dose was missed, skip it and go back to your regular dosing schedule.
To store this medicine:
Precautions While Using This Medicine
Do not take any other medicines without checking with your doctor first. This includes prescription and nonprescription medicines. This also includes food supplements, herbs and vitamins. To do so may increase the chance of side effects from amprenavir or other medicines.
This medicine may decrease the effects of some oral contraceptives (birth control pills). To avoid unwanted pregnancy, it is a good idea to use some additional contraceptive measures while being treated with amprenavir.
For patients with diabetes: Amprenavir may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.
Do not take vitamin E supplements while you are taking amprenavir. At recommended dosages, amprenavir supplies more than the Reference Daily Intake of vitamin E for adults and children.
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects, especially increases in blood sugar.
Amprenavir does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contamination through blood. HIV may be acquired from or spread to others through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom (****œrubber"). Only use condoms made of latex, and use them every time you have vaginal, anal, or oral sex . The use of a spermicide (such as nonoxynol-9) may also help prevent the spread of HIV if it is not irritating to the vagina, rectum, or mouth. Spermicides have been shown to kill HIV in lab tests. Do not use oil-based jelly, cold cream, baby oil, or shortening as a lubricant-these products can cause the condom to break. Lubricants without oil, such as K-Y Jelly , are recommended. Women may wish to carry their own condoms. Birth control pills and diaphragms will help protect against pregnancy, but they will not prevent someone from giving or getting the AIDS virus. If you inject drugs, get help to stop. Do not share needles or equipment with anyone. In some cities, more than half of the drug users are infected, and sharing even 1 needle or syringe can spread the virus. If you have any questions about this, check with your health care professional.
Side Effects of This Medicine
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
It is possible that the fat on your body may distribute itself differently or you may accumulate more body fat while you are taking this medicine. If you have concerns about this, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT