Please be patient! It may take up to ONE minute to load all the Engines.
Problems? Please contact our support.
In the U.S.-
Histrelin ( his-TREL-in) is a hormone similar to one normally released from the hypothalamus gland in the brain. Histrelin is used in the treatment of central precocious puberty (CPP), a condition that causes early puberty in boys (before 9.5 years of age) and in girls (before 8 years of age). Histrelin works by decreasing the amount of estrogen and testosterone in the blood.
When given regularly to boys and girls, this medicine helps to delay early puberty, slowing down the development of breasts in girls and the development of genital areas in boys and girls. This medicine delays puberty in a child only as long as the child continues to receive it.
Suppressing estrogen can cause thinning of the bones or slowing of their growth. Slowing the growth of bones is a positive effect in girls and boys whose bones grow too fast when puberty begins too early. Boys and girls may benefit by adding inches to their adult height when histrelin helps their bones grow at the proper and expected rate for children.
This medicine is available only with your doctor's prescription, in the following dosage form(s):
Before Using This Medicine
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For histrelin, the following should be considered:
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to histrelin or to gonadotropin-releasing hormone-like medicines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy- Histrelin use is not recommended during pregnancy. Histrelin has not been studied in pregnant women. It has been shown to cause problems in animals, such as low birth weights and a decrease in the number of successful pregnancies.
Breast-feeding- It is not known whether histrelin passes into breast milk. However, use of histrelin is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
Children- When used to treat a child for central precocious puberty, histrelin will stop having an effect soon after the child stops using it, and puberty should occur normally. It is not known if using histrelin around the time of puberty will cause changes in a boy's or a girl's future ability to have babies. Their chances of having children are thought to be normal.
It is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.
Proper Use of This Medicine
You will be given a fact sheet with your prescription for histrelin that explains how to prepare and give the injection. Carefully read the fact sheet . If you have any questions about using histrelin, ask your health care professional.
There are several important steps that will help you successfully prepare the histrelin injection. To draw the histrelin up into the syringe correctly, you need to follow these steps:
How to prepare the histrelin dose :
Choose the proper area of the body, such as the upper arms, thighs, or abdomen, to inject the dose of histrelin. The site should be changed between injections as directed by your doctor.
How to inject the histrelin dose :
For patients using disposable syringes :
Use this medicine only as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Using too much may increase the chance of unwanted side effects, while using too little may not control the onset of puberty .
Many boys and girls who have central precocious puberty will not feel sick or will not understand the importance of using the medicine regularly. It is very important that the medicine is used exactly as directed and that the proper amount is used at the proper time . It works best when there is a constant amount in the blood. To help keep the amount of histrelin in the blood constant, histrelin must be given on a regular schedule.
The dose of histrelin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of histrelin. If your dose is different, do not change it unless your doctor tells you to do so.
Check with your doctor if you miss a dose of this medicine.
To store this medicine:
Precautions While Using This Medicine
All scheduled visits to the doctor should be kept . This is especially important for children using the medicine for treatment of central precocious puberty as their condition improves. The child's progress still must be checked by the doctor after the medicine is no longer being used .
Tell the doctor if histrelin does not stop puberty from progressing within 6 to 8 weeks after starting treatment with histrelin . You may notice puberty progressing in your child for the first few weeks of therapy. These signs should stop within 4 weeks after your child begins treatment with histrelin.
This medicine may cause blurred vision, difficulty in reading, or other changes in vision . It may also cause some people to feel dizzy or lightheaded and impair their ability to use machines or do dangerous tasks. If these problems occur, report them to your doctor .
Side Effects of This Medicine
Side Effects of This Medicine
In the first few weeks of therapy, you may notice puberty progressing in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks after histrelin has had time to begin working properly, you should see signs in boys and girls that puberty is stopping.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Other side effects not listed above also may occur in some patients. If you notice any other effects, check with your doctor.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT