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Glyburide and Metformin
Why is this medication prescribed?
The combination of glyburide and metformin is used to treat type 2 (noninsulin-dependent) diabetes (formerly called 'adult-onset') in people whose diabetes cannot be controlled by diet and exercise alone. Glyburide belongs to a class of drugs called sulfonylureas, and metformin is in a class of drugs called biguanides. Glyburide lowers blood sugar by stimulating the pancreas, the organ that makes insulin. Insulin helps control blood sugar levels. The pancreas must produce insulin for this medication to work. Metformin helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose you get from your diet and the amount made by your liver. It also helps your body use its own insulin more effectively. Glyburide and metformin are not used to treat type 1 (insulin-dependent) diabetes (formerly called 'juvenile-onset').
How should this medicine be used?
Glyburide and metformin combination comes as a tablet to take by mouth. It is usually taken one to two times daily with meals. Your doctor may gradually increase your dose, depending on your response to glyburide and metformin. Monitor your blood glucose closely. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glyburide and metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Glyburide and metformin combination controls diabetes but does not cure it. Continue to take glyburide and metformin even if you feel well. Do not stop taking glyburide and metformin without talking to your doctor.
Other uses for this medicine
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking glyburide and metformin,
What special dietary instructions should I follow?
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. Calorie reduction, weight loss, and exercise will help control your diabetes and will also make glyburide and metformin work better. It is important to eat a healthy diet. Alcohol increases blood sugar and can affect the amount of lactic acid made. Ask your doctor for information on how much is safe to drink.
What should I do if I forget a dose?
Before you start taking glyburide and metformin, ask your doctor what to do if you forget to take a dose or accidently take an extra dose. Write these directions down so you can refer to them later.
As a general rule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Glyburide and metformin are used to control the amount of sugar (glucose) in your blood. You should know the symptoms of low and high blood sugar and what to do if you have them.
If you have any of the symptoms of low blood sugar, eat or drink a food or beverage with sugar in it, such as hard candy or fruit juice, and call your doctor immediately. The symptoms of low blood sugar include:
If you have any of the symptoms of high blood sugar (hyperglycemia), call your doctor immediately. The symptoms of high blood sugar include:
Although side effects from glyburide and metformin are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
Keep this medication in the container it came in (which is light resistant), tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to glyburide and metformin. Your doctor may order other lab tests to check your response to glyburide and metformin.
To monitor the effectiveness of glyburide and metformin, measure the amount of sugar (glucose) in your blood or urine (when blood sugar is above a certain high level, you will have sugar in your urine). For measuring the amount of glucose in your blood, you can use a blood glucose meter. For the urine measurements, you will need special paper tapes, tablets, or plastic strips that change color depending on how much sugar is present. Your doctor also may ask you to test your urine for ketones (substances present when diabetes is not under control). Follow your doctor's directions for testing your urine and blood and for recording the results. If your blood sugar is high or if sugar or ketones are present in your urine, call your doctor.
Keep yourself and your clothes clean. Wash cuts, scrapes, and other wounds quickly, and do not let them get infected.
Wear medical alert identification (a bracelet or tag) that says you have type 2 diabetes.
Tell your doctor if you become seriously dehydrated (have lost a large amount of body fluids) or have severe vomiting, diarrhea, or fever. Tell your doctor if you have a heart attack or stroke.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Last updated: Tue, 06 Jan 2009 00:20:03 GMT