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Other drug names: A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9   

Meprobamate and Aspirin (Systemic)

Brand Names

In the U.S.-

  • Epromate-M
  • Equagesic
  • Heptogesic
  • Meprogesic
  • Meprogesic Q
  • Micrainin

In Canada-

  • Equagesic

**  In Canada, Equagesic also contains ethoheptazine citrate

Category

  • Analgesic

Description

Meprobamate (me-proe-BA-mate ) and aspirin (AS-pir-in ) combination is used to relieve pain, anxiety, and tension in certain disorders or diseases.

This medicine is available only with your doctor's prescription, in the following dosage form:

    Oral
  • Tablets (U.S. and Canada)



Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For meprobamate and aspirin combination, the following should be considered:

Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to meprobamate or to medicines like meprobamate such as carbromal, carisoprodol, mebutamate, or tybamate, or to aspirin or other salicylates, including methyl salicylate (oil of wintergreen), or to any of the following medicines:

  • Diclofenac (e.g., Voltaren)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Fenoprofen (e.g., Nalfon)
  • Floctafenine (e.g., Idarac)
  • Flurbiprofen, oral (e.g., Ansaid)
  • Ibuprofen (e.g., Motrin)
  • Indomethacin (e.g., Indocin)
  • Ketoprofen (e.g., Orudis)
  • Ketorolac (e.g., Toradol)
  • Meclofenamate (e.g., Meclomen)
  • Mefenamic acid (e.g., Ponstel)
  • Naproxen (e.g., Naprosyn)
  • Oxyphenbutazone (e.g., Tandearil)
  • Phenylbutazone (e.g., Butazolidin)
  • Piroxicam (e.g., Feldene)
  • Sulindac (e.g., Clinoril)
  • Suprofen (e.g., Suprol)
  • Tiaprofenic acid (e.g., Surgam)
  • Tolmetin (e.g., Tolectin)
  • Zomepirac (e.g., Zomax)

Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy- Meprobamate (contained in this combination medicine) has been reported to increase the chance of birth defects if taken during the first 3 months of pregnancy.

Studies in humans have not shown that aspirin (contained in this combination medicine) causes birth defects. However, studies in animals have shown that aspirin causes birth defects. Some reports have suggested that too much use of aspirin late in pregnancy may cause a decrease in the newborn's weight and possible death of the fetus or newborn infant. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects. However, regular use of aspirin late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or in the newborn infant. Also, use of aspirin during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery or in the newborn infant. In addition, too much use of aspirin during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery.

Breast-feeding- Meprobamate (contained in this combination medicine) passes into the breast milk and may cause drowsiness in babies of mothers taking this medicine. Although aspirin (contained in this combination medicine) passes into the breast milk, it has not been shown to cause problems in nursing babies.

Children- Do not give a medicine containing aspirin to a child with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing this with your child's doctor . This is very important because aspirin may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin (contained in this combination medicine), especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

Teenagers- Teenagers with fever or other symptoms of a virus infection, especially flu or chickenpox, should check with a doctor before taking this medicine . The aspirin in this combination medicine may cause a serious illness called Reye's syndrome in teenagers with fever caused by a virus infection, especially flu or chickenpox.

Older adults- Elderly people may be especially sensitive to the effects of meprobamate and aspirin. This may increase the chance of side effects during treatment.

Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking meprobamate and aspirin combination, it is especially important that your health care professional know if you are taking any of the following:

  • Anticoagulants (blood thinners) or
  • Carbenicillin by injection (e.g., Geopen) or
  • Cefamandole (e.g., Mandol) or
  • Cefoperazone (e.g., Cefobid) or
  • Cefotetan (e.g., Cefotan) or
  • Dipyridamole (e.g., Persantine) or
  • Divalproex (e.g., Depakote) or
  • Heparin or
  • Inflammation or pain medicine, except narcotics, or
  • Moxalactam (e.g., Moxam) or
  • Pentoxifylline (e.g., Trental) or
  • Plicamycin (e.g., Mithracin) or
  • Ticarcillin (e.g., Ticar) or
  • Valproic acid (e.g., Depakene)-Taking these medicines together with aspirin may increase the chance of bleeding
  • Antidiabetics, oral (diabetes medicine you take by mouth)-Aspirin may increase the effects of the antidiabetic medicine; a change in dose may be needed if meprobamate and aspirin combination is taken regularly
  • Central nervous system (CNS) depressants (medicine that causes drowsiness) or
  • Tricyclic antidepressants (medicine for depression)-Taking these medicines with meprobamate and aspirin combination may increase the CNS depressant effects
  • Methotrexate (e.g., Mexate)-The chance of serious side effects may be increased
  • Probenecid (e.g., Benemid)-Aspirin may keep probenecid from working properly in the treatment of gout
  • Sulfinpyrazone (e.g., Anturane)-Aspirin may keep sulfinpyrazone from working properly in the treatment of gout; also, there may be an increased chance of bleeding
  • Urinary alkalizers (medicine that makes the urine less acid, such as acetazolamide [e.g., Diamox], calcium- and/or magnesium-containing antacids, dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane], potassium or sodium citrate and/or citric acid, sodium bicarbonate [baking soda])-These medicines may make aspirin less effective by causing it to be removed from the body more quickly
  • Vancomycin (e.g., Vancocin)-Hearing loss may occur and may lead to deafness

Other medical problems- The presence of other medical problems may affect the use of meprobamate and aspirin combination. Make sure you tell your doctor if you have any other medical problems, especially:
  • Alcohol abuse (or history of) or
  • Drug abuse or dependence (or history of)-Dependence on meprobamate may develop
  • Anemia or
  • Stomach ulcer or other stomach problems-Aspirin may make your condition worse
  • Asthma, allergies, and nasal polyps (history of) or
  • Kidney disease or
  • Liver disease-The chance of side effects may be increased.
  • Epilepsy-The risk of seizures may be increased
  • Gout-Aspirin may make this condition worse and may also lessen the effects of some medicines used to treat gout
  • Hemophilia or other bleeding problems-The chance of bleeding may be increased by aspirin
  • Porphyria-Meprobamate may make the condition worse


Proper Use of This Medicine

Take this medicine with food or a full glass (8 ounces) of water to lessen stomach irritation.

Do not take this medicine if it has a strong vinegar-like odor . This odor means the aspirin in it is breaking down. If you have any questions about this, check with your health care professional.

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much meprobamate is taken, it may become habit-forming. Also, taking too much aspirin may cause stomach problems or lead to medical problems because of an overdose.

Dosing-

The dose of meprobamate and aspirin combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of meprobamate and aspirin combination. If your dose is different, do not change it unless your doctor tells you to do so:

  • Adults-Oral, 1 or 2 tablets three or four times a day, as needed.
  • Children up to 12 years of age: Use is not recommended.

Storage-

To store this medicine:

  • Keep this medicine out of the reach of children. Overdose of meprobamate is very dangerous in children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.


Precautions While Using This Medicine

If you will be taking this medicine regularly for a long time:

  • Your doctor should check your progress at regular visits.
  • Check with your doctor at least every 4 months to make sure you need to continue taking this medicine.

If you will be taking this medicine in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take . If any contain aspirin or other salicylates (including bismuth subsalicylate [e.g., Pepto-Bismol]), be especially careful. Taking or using any of these medicines while taking this combination medicine containing aspirin may lead to overdose. If you have any questions about this, check with your health care professional.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine .

Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with this medicine, especially if you are taking the medicine in high doses or for a long time. Check with your doctor if you have any questions about this.

Too much use of this medicine together with certain other medicines may increase the chance of stomach problems. Therefore, do not regularly take this medicine together with any of the following medicines, unless directed to do so by your medical doctor or dentist:

  • Acetaminophen (e.g., Tylenol)
  • Diclofenac (e.g., Voltaren)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Fenoprofen (e.g., Nalfon)
  • Floctafenine (e.g., Idarac)
  • Flurbiprofen (oral) (e.g., Ansaid)
  • Ibuprofen (e.g., Motrin)
  • Indomethacin (e.g., Indocin)
  • Ketoprofen (e.g., Orudis)
  • Ketorolac (e.g., Toradol)
  • Meclofenamate (e.g., Meclomen)
  • Mefenamic acid (e.g., Ponstel)
  • Naproxen (e.g., Naprosyn)
  • Phenylbutazone (e.g., Butazolidin)
  • Piroxicam (e.g., Feldene)
  • Sulindac (e.g., Clinoril)
  • Tiaprofenic acid (e.g., Surgam)
  • Tolmetin (e.g., Tolectin)

If you are taking a laxative containing cellulose, do not take it within 2 hours of taking this medicine. Taking these medicines close together may make this medicine less effective by preventing the aspirin (contained in this combination medicine) from being absorbed by your body.

For diabetic patients:

  • False urine sugar test results may occur if you take 8 or more 325-mg (5-grain) doses of aspirin (contained in this combination medicine) every day for several days in a row. Smaller doses or occasional use of aspirin usually will not affect urine sugar tests. If you have any questions about this, check with your doctor, especially if your diabetes is not well controlled.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by this medicine.

If you plan to have surgery, including dental surgery, do not take aspirin (contained in this combination medicine) for 5 days before the surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

If you think you or someone else may have taken an overdose of this medicine, get emergency help at once . Taking an overdose of this medicine or taking alcohol or other CNS depressants with it may lead to unconsciousness and possibly death. Some signs of an overdose are continuing ringing or buzzing in ears; any hearing loss; severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; staggering; and slow heartbeat.

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

Meprobamate (contained in this combination medicine) may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.


Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

  • Rare
    • Wheezing, shortness of breath, troubled breathing, or tightness in chest 

  • Symptoms of overdose
    • Any loss of hearing;  bloody urine;  confusion (severe);  convulsions (seizures) ;  diarrhea (severe or continuing);  dizziness or lightheadedness (continuing);  drowsiness (severe);  fast or deep breathing;  hallucinations (seeing, hearing, or feeling things that are not there);  headache (severe or continuing);  increased sweating;  nausea or vomiting (continuing);  nervousness or excitement (severe);  ringing or buzzing in ears (continuing);  slow heartbeat ;  slurred speech;  staggering ;  stomach pain (severe or continuing);  unexplained fever;  unusual or uncontrolled flapping movements of the hands, especially in elderly patients;  unusual thirst;  vision problems;  weakness (severe) 

  • Symptoms of overdose in children
    • Changes in behavior;  drowsiness or tiredness (severe);  fast or deep breathing 

Also, check with your doctor as soon as possible if any of the following side effects occur:

  • Rare
    • Bloody or black, tarry stools;  confusion ;  skin rash, hives, or itching;  sore throat and fever;  unusual bleeding or bruising ;  unusual excitement;  unusual tiredness or weakness;  vomiting of blood or material that looks like coffee grounds 

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

  • More common
    • Drowsiness;  heartburn or indigestion ;  nausea with or without vomiting;  stomach pain (mild) 

  • Less common
    • Blurred vision or change in near or distant vision;  dizziness or lightheadedness;  headache  

After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:

  • Clumsiness or unsteadiness;  confusion ;  convulsions (seizures);  hallucinations (seeing, hearing, or feeling things that are not there);  increased dreaming;  muscle twitching ;  nausea or vomiting;  nervousness or restlessness;  nightmares;  trembling;  trouble in sleeping 

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.



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Last updated: Tue, 06 Jan 2009 00:20:03 GMT
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